Detalhe da pesquisa
1.
Discovery of oxindole-based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation.
Arch Pharm (Weinheim)
; 356(2): e2200407, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36403191
2.
Combination of an Oxindole Derivative with (-)-ß-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells.
Molecules
; 28(13)2023 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446914
3.
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment.
Toxicol Mech Methods
; 33(5): 349-363, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36253940
4.
Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
Bioorg Chem
; 99: 103767, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325332
5.
Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives.
Bioorg Chem
; 101: 104020, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32599366
6.
Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones.
Bioorg Chem
; 66: 46-62, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27016713
7.
Ring expansions of acyloxy nitroso compounds.
Tetrahedron Lett
; 56(43): 5870-5873, 2015 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26663984
8.
Synthesis, cytotoxicity, docking study, and tubulin polymerization inhibitory activity of novel 1-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxanilides.
Arch Pharm (Weinheim)
; 347(9): 658-67, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24996189
9.
Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.
Pharmaceuticals (Basel)
; 17(5)2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38794229
10.
Assessing the Antiproliferative Potential of a Novel Combretastatin A4 Derivative via Modulating Apoptosis, MAPK/ERK and PI3K/AKT Pathways in Human Breast Cancer Cells.
Front Biosci (Landmark Ed)
; 28(8): 185, 2023 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37664933
11.
Investigation of Simultaneous and Sequential Cooperative Homotropic Inhibitor Binding to the Catalytic Chamber of SARS-CoV-2 RNA-dependent RNA Polymerase (RdRp).
Cell Biochem Biophys
; 81(4): 697-706, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37658974
12.
Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives.
Arch Pharm (Weinheim)
; 345(7): 535-48, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22592968
13.
Examination of the Validity of Skin Ultrasound to Quantitate Skin Involvement for Multicenter Clinical Trials in Patients with Systemic Sclerosis (SSc): A Systematic Literature Review (SLR).
ACR Open Rheumatol
; 4(3): 247-253, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34918494
14.
Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFRL858R/T790M Mutations.
Pharmaceuticals (Basel)
; 15(7)2022 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35890154
15.
Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies.
Nat Prod Res
; 36(4): 994-998, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33121282
16.
OMA1520 and OMA1774, novel 1,2,4-triazole bearing analogs of combretastatin A-4, inhibit hepatocellular carcinoma: Histological and immunohistochemical studies.
Biomed Pharmacother
; 138: 111417, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33752057
17.
Chemical Composition of the Red Sea Green Algae Ulva lactuca: Isolation and In Silico Studies of New Anti-COVID-19 Ceramides.
Metabolites
; 11(12)2021 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34940574
18.
Flavonoids of Salvadora persica L. (meswak) and its liposomal formulation as a potential inhibitor of SARS-CoV-2.
RSC Adv
; 11(22): 13537-13544, 2021 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35423847
19.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
RSC Adv
; 10(33): 19570-19575, 2020 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35515460
20.
In silico identification of SARS-CoV-2 spike (S) protein-ACE2 complex inhibitors from eight Tecoma species and cultivars analyzed by LC-MS.
RSC Adv
; 10(70): 43103-43108, 2020 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35514923