1.
J Org Chem
; 87(21): 14005-14015, 2022 11 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36210518
RESUMO
A facile and effective tandem reaction of ynones and methyl salicylates was developed to obtain a broad range of 3-acyl chromones in moderate-to-excellent yields. This protocol underwent a Michael addition and cyclization process, which exhibited easily accessible substrates, broad substrate scope, and high regioselectivity under mild and transition-metal-free conditions. Moreover, gram-scale reaction and further chemical transformation of the products were also further studied.