Comparative analyses of arthroscopic and open repairs of lateral ligament complex injuries of the ankle: a systematic review and meta-analysis of the medium-term outcomes.

PURPOSE: Little is known regarding the comparative analyses of the medium-term outcomes (with a mean minimum follow-up period of 24 months), between arthroscopic and open repairs of lateral ligament complex (LLC) injuries of the ankle. Thus, in this study, we aimed to explore the comparative analyses regarding the medium-term follow-up outcomes of these repairs, by conducting a systematic review and meta-analysis. METHODS: The systematic review and meta-analysis were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines; data were extracted from the PubMed and Google Scholar databases. From an initial search, a total of 1182 abstracts (280 and 902 abstracts, from PubMed and Google Scholar, respectively) were found and screened in accordance with the eligibility criteria. Subsequently, six articles were found to be eligible for further review. RESULTS: A total of 419 patients underwent surgical repairs; 205 and 214 patients underwent arthroscopic and open repairs, respectively. The mean minimum follow-up period was 29.2 months. The medium-term follow-up for arthroscopic LLC repairs was found to be superior to that of open LLC repairs, with more favorable outcomes; as evidenced by better clinical scores, lower pooled complication rates, earlier return times to pre-injury sport, and higher early sport ratios. CONCLUSIONS: The findings of this systematic review and meta-analysis support near-future developments validating arthroscopic repair as the new gold standard for LLC repairs, similarly to arthroscopic ligament and tendon repairs, as well as arthroscopic reconstruction surgeries, of the knee and shoulder.

Nonoperative and Operative Soft-Tissue and Cartilage Regeneration and Orthopaedic Biologics of the Foot and Ankle: An Orthoregeneration Network Foundation Review.

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the foot and ankle (including acute traumatic injuries and fractures, tumor, infection, osteochondral lesions, arthritis, and tendinopathy) and procedures, including osteotomy or fusion. Promising and established treatment modalities include 1) bone-based therapies (such as cancellous or cortical autograft from the iliac crest, proximal tibia, and/or calcaneus, fresh-frozen or freeze-dried cortical or cancellous allograft, including demineralized bone matrix putty or powder combined with growth factors, and synthetic bone graft substitutes, such as calcium sulfate, calcium phosphate, tricalcium phosphate, bioactive glasses (often in combination with bone marrow aspirate), and polymers; proteins such as bone morphogenic proteins; and platelet-derived growth factors; 2) cartilage-based therapies such as debridement, bone marrow stimulation (such as microfracture or drilling), scaffold-based techniques (such as autologous chondrocyte implantation [ACI] and matrix-induced ACI, autologous matrix-induced chondrogenesis, matrix-associated stem cell transplantation, particulated juvenile cartilage allograft transplantation, and minced local cartilage cells mixed with fibrin and platelet rich plasma [PRP]); and 3) blood, cell-based, and injectable therapies such as PRP, platelet-poor plasma biomatrix loaded with mesenchymal stromal cells, concentrated bone marrow aspirate, hyaluronic acid, and stem or stromal cell therapy, including mesenchymal stem cell allografts, and adipose tissue-derived stem cells, and micronized adipose tissue injections. LEVEL OF EVIDENCE: Level V, expert opinion.

Minimally invasive surgery versus an arthroscopic procedure for the first metatarsophalangeal arthrodesis: A comparative study of the effectiveness and safety profile.

INTRODUCTION: First metatarsophalangeal (MTP) arthrodesis is a common procedure for treating degeneration in the MTP joint. Open arthrodesis is a conventional procedure that provides acceptable results but is more invasive than minimally invasive or arthroscopic arthrodesis. However, little is known about the different outcomes between minimally invasive surgery (MIS) and arthroscopic surgery (AS) for MTP arthrodesis. This study was performed to compare the outcomes of the first MTP joint preparation for arthrodesis regarding the effectiveness of articular surface preparation and safety between MIS and the arthroscopic procedure in cadaveric specimens. METHODS: Sixteen cadaveric feet were collected in this study from eight cadavers. The potential exclusion criteria were significantly decomposed or deformed joint. All feet were randomly allocated into two groups, eight feet for the MIS (under fluoroscopic control) group and eight feet for the arthroscopic group. One foot in the AS group was excluded because the position of an arthroscopic portal was incorrect. All feet were operated on by four fellowship-trained foot and ankle orthopedic surgeons who also had prior clinical experience with the arthroscopic and minimal invasive procedure. Following a complete procedure in each specimen, all feet were dissected and the areas of joint preparation on the metatarsal and phalangeal sides were recorded via photography and the ImageJ program. Injury to the adjacent structure was noted in each specimen. All data were analyzed via the IBM SPSS program version 22 and GraphPad to compare the outcomes between the two groups. RESULTS: The average age of the cadavers was 68.6 ± 12.3 years. The average areas of joint preparation on the metatarsal and phalangeal sides were 136.97 and 99.08 mm2, respectively. The average areas of joint preparation on the metatarsal sides were 154.26 and 117.21 mm2 in the MIS and arthroscopic groups, respectively (p value = 0.353). The average areas of joint preparation on the phalangeal sides were 82.46 and 118.08 mm2 in the MIS and arthroscopic groups, respectively (p value = 0.151). Regarding the ratio of prepared area/mean estimated fusion contact area, there was no significant difference of a ratio on metatarsal side with p value as 0.285. However, a higher level of ratio on phalangeal side was found in the arthroscopic group with p value as 0.085. For the safety profiles, the rate of adjacent injury was insignificantly higher in the MIS group (37.5%) than the arthroscopic group (0%) (p value = 0.20). All injuries were found at the extensor hallucis longus tendon. CONCLUSIONS: There were no significant differences of the effectiveness of articular surface preparation between the MIS and arthroscopic groups. However, the arthroscopic procedure seemed to provide higher rate of prepared surface area on phalangeal side and be safer to the adjacent structures than MIS for this arthrodesis.

Relationships among subjective patient-reported outcome, quality of life, and objective gait characteristics using wearable foot inertial-sensor assessment in foot-ankle patients.

BACKGROUND: This study aimed to determine the relationships between subjective validated patient-reported outcomes and health-related quality of life, to objective gait characteristics in patients with foot-ankle conditions. Objective gait characteristics were obtained using a wearable foot inertial-sensor device as well as by assessing the relationships between spatiotemporal or gait parameters by analyzing the inter-metric correlations. METHODS: Fifty-two patients with foot-ankle conditions (37 women/15 men, aged 21-75 years) were included in this study. Clinical assessments, including evaluations of validated patient-reported outcomes using visual analog scale foot and ankle score, health-related quality of life using validated Short Form-36, and gait characteristics using a wearable foot inertial-sensor device, were performed and recorded for each patient. RESULTS: A significant negative correlation was observed between the physical component summary (PCS) and maximal cadence (r = - 0.308, P = 0.025). Significant positive correlations were noted between mean walking speed and mean cadence (r = 0.776, P < 0.001) and between maximal walking speed and mean step length (r = 0.498, P < 0.001). Significant negative correlations were found between the mean cadence and mean step length (r = - 0.491, P < 0.001) and between maximal cadence and mean step length (r = - 0.355, P = 0.009). CONCLUSIONS: Cadence is an important objective spatiotemporal parameter to assess in foot and ankle patients as it relates well to outcome, with a significantly negatively correlation to subjectively reported PCS in health-related quality of life. Based on inter-metric relationships, an increased cadence might be used to maintain walking speed as a compensatory mechanism in patients with foot-ankle conditions.

Talar-sided osteochondral lesion of the subtalar joint following the intra-articular calcaneal fracture: study via a modified computed tomography mapping analysis.

INTRODUCTION: This study is to report the prevalence of osteochondral lesions in subtalar joint following intra-articular calcaneal fracture, including the relationship between fracture severity and lesion characteristics, using modified computed tomography (CT) mapping analysis. METHODS: Thirty patients with intra-articular calcaneal fracture who were preoperatively imaged with modified CT mapping analysis were recruited. The presence of talar-sided osteochondral lesions (OLTS) of subtalar joint was noted with lesion area defined by Akiyama's mapping classification. Lesion severity was assessed via Ferkel's classification, and fracture severity via Sanders' classification. RESULTS: Lesions were found in 28 patients (93.3%), mostly at anterior [16 (57.1%) lesions] or central [13 (46.4%) lesions] areas of posterior talar facet. Most common grade of lesion severity was grade I (mild) seen in 24 (80%) patients. Most fractures were classified as Sanders' grade III and IV with 12 (40%) and 12 (40%) patients noted, respectively. High severity of fracture denoted by Sanders' grade IV showed a trend of higher prevalence of OLTS at anterior and central sites of posterior talar facet (P = 0.181). Lesion severity was significantly higher in patients with double lesions than patients with single lesions (P = 0.005). However, OLTS were not significantly related with osteoarthritic changes in follow-up radiographs (P > 0.05). CONCLUSIONS: The prevalence of OLTS is very high following intra-articular calcaneal fractures. Most lesions occur at anterior or central area of posterior talar facet and are more likely to occur in patients with higher fracture severity. Lesion severity was significantly higher in patients with double lesions than patients with single lesions.

Validity and reliability of Thai version of the Foot and Ankle Outcome Score in patients with arthritis of the foot and ankle.

BACKGROUND: Although the Foot and Ankle Outcome Score (FAOS) is commonly used in several languages for a variety of foot disorders, it has not been validated specifically for foot and ankle arthritic conditions. The aims of the present study were to translate the original English FAOS into Thai and to evaluate the validity and reliability of the Thai version of the FAOS for the foot and ankle arthritic conditions. METHODS: The original FAOS was translated into Thai using forward-backward translation. The Thai FAOS and validated Thai Short Form-36 (SF-36®) questionnaires were distributed to 44 Thai patients suffering from arthritis of the foot and ankle to complete. For validation, Thai FAOS scores were correlated with SF-36 scores. Test-retest reliability and internal consistency were also analyzed in this study. RESULTS: The Thai FAOS score demonstrated sufficient correlation with SF-36 total score in Pain (Pearson's correlation coefficient (r)=0.45, p=0.002), Symptoms (r=0.45, p=0.002), Activities of Daily Living (ADL) (r=0.47, p=0.001), and Quality of Life (QOL) (r=0.38, p=0.011) subscales. The Sports and Recreational Activities (Sports & Rec) subscale did not correlate significantly with the SF-36® (r=0.20, p=0.20). Cronbach's alpha, a measure of internal consistency, for the five subscales was as follows: Pain, 0.94 (p<0.001); Symptoms, 0.58 (p<0.001); ADL, 0.96 (p<0.001); Sports & Rec, 0.79 (p<0.001); and QOL, 0.93 (p<0.001). The intraclass correlation coefficient (ICC) of a major subscale of ADL, containing 17 items, was significant at 0.33 (p=0.013; 95% confidence interval, 0.04-0.57). CONCLUSION: The Thai FAOS demonstrated sufficient levels of construct and content validity for the evaluation of foot and ankle arthritis. Although reliability was satisfactory for the major subscale ADL, it was not sufficient for the minor subscales. Our findings suggest that it can be used as a disease-specific instrument to evaluate foot and ankle arthritis and can complement other reliable outcome surveys.

Health-related quality of life and functional outcomes in ankle arthritis patients based on treating with and without total ankle replacement surgery.

BACKGROUND: Little is known about health-related quality of life and functional outcomes in candidate patients with indications for total ankle replacement (TAR) when compared to patients without indications. This study is to compare the quality of life and functional outcomes in patients who have ankle arthritis and are with and without indicationsfor TAR. MATERIAL AND METHOD: An evaluation was conducted on 40 patients who had developed ankle arthritis from various causes. Forty patients were divided into two groups in accordance with their indications for TAR; the TAR-indicated group (11 patients) and the non-TAR indicated group (29 patients). Medical records of each patient were reviewed to collect pre- treatment visual analogue scale (VAS-pain) scores, visual analogue scale foot and ankle (VAS-FA) scores, health-related quality of life scores as ascertained from short-form 36 (SF-36), and baseline data. RESULTS: VAS-pain, VAS-FA, and SF-36 scores were insignificantly poorer in TAR-indicated group (p>0.05). There were no significant differences in scores among the three groups of treatment as non-operative treatments, joint-preserving treatments, and joint-sacrificing treatments or between TAR-indicated group and arthrodesis group (p>0.05). There were significant correlations between VAS-pain and VAS-FA scores (Pearson's r-correlation-coefficient (r) = -0.389; p = 0.019) or between VAS-FA and SF-36 scores (r = 0.564; p<0.01). There were no significant correlations between VAS-pain and SF-36 scores (p>0.05). Only SF-36 scores were significantly negative correlated with radiographic grades in Takakura (r = -0.382; p 0.015) and the author's (r = -0.378; p = 0.016) classifications. CONCLUSION: Quality of life and functional outcomes in candidate patients with indications for TAR was insignificantly poorer than those in the patients without indications or patients in arthrodesis subgroup. Poorer radiographic grades of ankle arthritis were significantly correlated with poorer quality of life, which is reflected via SF-36 scores.

Validity and Reliability of Thai Version of the Foot and Ankle Ability Measure (FAAM) Subjective Form.

BACKGROUND: Self-administered questionnaires have become an important aspect for clinical outcome assessment of foot and ankle-related problems. The Foot and Ankle Ability Measure (FAAM) subjective form is a region-specific questionnaire that is widely used and has sufficient validity and reliability from previous studies. OBJECTIVE: Translate the original English version of FAAM into a Thai version and evaluate the validity and reliability of Thai FAAM in patients with foot and ankle-related problems. MATERIAL AND METHOD: The FAAM subjective form was translated into Thai using forward-backward translation protocol. Afterward, reliability and validity were tested. Following responses from 60 consecutive patients on two questionnaires, the Thai FAAM subjective form and the short form (SF)-36, were used. The validity was tested by correlating the scores from both questionnaires. The reliability was adopted by measuring the test-retest reliability and internal consistency. RESULTS: Thai FAAM score including activity of daily life (ADL) and Sport subscale demonstrated the sufficient correlations with physical functioning (PF) and physical composite score (PCS) domains of the SF-36 (statistically significant with p < 0.001 level and ≥ 0.5 values). The result of reliability revealed highly intra-class correlation coefficient as 0.8 and 0.77, respectively from test-retest study. The internal consistency was strong (Cronbach alpha = 0.94 and 0.88, respectively). CONCLUSION: The Thai version of FAAM subjective form retained the characteristics of the original version and has proved a reliable evaluation instrument for patients with foot and ankle-related problems.

The Anterior Cruciate Ligament Reconstruction with the Peroneus Longus Tendon: A Biomechanical and Clinical Evaluation of the Donor Ankle Morbidity.

BACKGROUND: The purpose of this study was to report on ankle and foot functions via the holistic evaluations using clinical examination, functional scores assessment and isokinetic tests after harvesting autogenous peroneus longus tendons for anterior cruciate ligament (ACL) reconstruction focusing on the donor site morbidity with a minimum 1-year follow-up period. MATERIAL AND METHOD: The study included 24 patients who underwent ACL reconstruction using peroneus longus autograft and endobutton fixation. Results of ACL reconstruction were assessed via physical examination. Donor site morbidity of the foot and ankle after tendon-harvesting was assessed using American Orthopedic Foot-and-Ankle Society (AOFAS) for ankle-hindfoot score and Visual Analogue Score-Foot Ankle (VAS-FA). Isokinetic testing for the ankle was performed in 10 voluntary patients after surgery. RESULTS: Mean follow-up time was 12.8 months. Regarding the latest follow-up, anterior drawer tests of ankle showed normal findings in 83.3%, and 1+ anterior laxity in 16.7% of all patients. Mean pre- and postoperative AOFAS scores were 100.0 ± 0.0 and 96.0 ± 9.6, respectively at 6-month follow-up (p = 0.06). Mean pre- and postoperative VAS-FA scores were 99.7 ± 1.1 and 95.4 ± 12.0, respectively at - 13-month follow-up (p = 0.09). At 7-month follow-up by isokinetic testing, peak torques of eversion and inversion were significantly lower on the harvested ankle compared with the contralateral ankle at both velocities (60 degrees/second and 120 degrees/second, p < 0.05). CONCLUSION: Based on overall findings in the present study, the authors could not recommend the peroneus longus tendon as the first option of donor graft for ACL reconstruction due to the several morbidities particularly in the first 12 months after the operation. However, the peroneus longus tendon may be the option after other graft harvestings for the ligament reconstruction, which needs several tendon grafts in a patient with multi-directional instability of the knee due to some specific situation such as a traumatic knee dislocation.

Intraosseous concentration and inhibitory effect of different intravenous cefazolin doses used in preoperative prophylaxis of total knee arthroplasty.

BACKGROUND: The aim of this study was to compare the intraosseous concentrations and the inhibitory effects on the growth of Staphylococcus aureus of 1 g versus 2 g of intravenous (IV) prophylactic cefazolin in total knee arthroplasty (TKA). MATERIALS AND METHODS: Eighteen patients (21 knees) with primary knee osteoarthritis were divided into two groups receiving 1 g (12 patients: 14 knees) versus 2 g (six patients: seven knees) IV prophylactic cefazolin prior to the incision in TKA. Subchondral bone samples (proximal tibia, distal femur) were taken during the operation. These samples were analyzed for intraosseous concentration of cefazolin and their inhibitory effects on the growth of S. aureus, using high-performance liquid chromatography (HPLC) and agar disc diffusion bioassays. RESULTS: The mean intraosseous concentration in the 2 g dose group was significantly higher than in the 1 g dose group in the proximal tibia (p = 0.007) and distal femur (p = 0.016). There were no significant differences between the two groups in terms of mean inhibitory effects in the proximal tibia or distal femur (p > 0.05). No significant correlations were found between the intraosseous concentrations and inhibitory effects in the proximal tibia (r = 0.18, p = 0.52) and distal femur (r = -0.29, p = 0.30). CONCLUSION: IV cefazolin at a dose of 2 g produced greater intraosseous concentrations overall than a dose of 1 g. However, the higher intraosseous concentrations did not correlate with higher inhibitory effects.

Heterotopic ossification following total ankle replacement: clinical significance and factors affecting its formation.

Little is known about the clinical significance of heterotopic ossification after total ankle replacement and the factors contributing to its occurrence. This study documented the incidence of heterotopic ossification in a large ankle arthroplasty series; identified potentially related patient, implant, and operative factors; and determined the strength of association of those factors with the clinical outcome. Ninety ankles in 88 primary ankle arthroplasty patients were followed for an average of 32.4 months. Scandinavian Total Ankle Replacement, Salto-Talaris, and INBONE ankle implants were used at the surgeon's discretion. Heterotopic ossification was measured and classified using methods previously described for total hip arthroplasty. Incidence, location, severity, predisposing factors, and outcomes were documented, and correlation between ossification severity and each examined factor was determined. Eighty percent and 95.6% of ankles showed heterotopic ossification on anteroposterior and lateral views, respectively, and 97.8% showed evidence on either anteroposterior or lateral views. Ossification grades 4 and 3 were most common, predominantly located at the medial gutter and posterior to the tibial component. No preoperative variables were associated with heterotopic ossification, but its presence on lateral radiographs correlated with insufficient coverage of the tibial or talar component. Only three ankles required heterotopic ossification resection because of recalcitrant pain. The incidence of heterotopic ossification following primary total ankle arthroplasty was higher in this series than previously reported.

Does the addition of computed tomography to computed radiography provide more value to final outcomes and treatment decisions in displaced intra-articular calcaneal fractures?

BACKGROUND: Little is known about the additional prognostic value of computed tomography (CT) in addition to computed radiography in displaced intra-articular calcaneal fractures. Thepresent study was undertaken to examine and compare the final radiographic outcomes and the prevalence of treatment methods of displaced intra-articular calcaneal fractures in patients with preoperative computed radiography alone vs. a combination ofcomputed radiography and computed tomogra- phy. MATERIAL AND METHOD: Thirty-four patients with 38 displaced intra-articular calcaneal fractures were divided into two groups: a group that was evaluated with computed tomography and computed radiography (17 patients; 20 fractures) and a group that was evaluated with computed radiography alone (17 patients; 18 fractures). Patient demographics, pre- operative and postoperative Bohler's angles, and fracture classifications were recorded. Postoperative outcomes were evaluated using calcanealfracture radiographic scores (modified Zwipp score). RESULTS: The mean age ofour patients in the present study was 43.3 ± 12.3 years. The mean age ofthe patients in the computed tomography group (48.4 ± 11.6 years) was significantly higher than that of the non-computed tomography group (37.6 ± 10.7 years, p = 0.005). The mean follow-up time was 17.4 ± 9.8 months. There was a significantly higher prevalence of open reduction and internalfixation in the computed tomography group versus the non-computed tomography group (p = 0.019). However there was no significant difference observed for the mean radiographic scores. Postoperatively, outcomes were satisfactory in both groups, although intra-articular alignment was significantly better in the computed tomography group (p = 0.020). CONCLUSION: The overall outcomes were comparable between the patient groups with computed tomography vs. those without computed tomography, exceptfor the superiority of postoperative intra-articular alignment in patients with computed tomography. Open reduction and internal fixation were more frequently performed in the patients with computed tomography than patients without computed tomography.

A Novel Update on the Management of Müller-Weiss Disease: Presentation of a Treatment Algorithm.

OBJECTIVE: Müller-Weiss disease (MWD) is a challenging condition involving the perinavicular region in the initial stages and subsequently the entire foot in the later stages. The goal of this article is to describe the pathomechanics, clinical evaluation, and nonoperative and operative treatment, including a treatment algorithm, based on current evidence and the combined authors' experience. DESIGN: We review the related articles and summarize the information about this condition. RESULTS: A number of related articles reveal that the treatments should focus on the management of degenerative regions and deformity correction to restore normal foot alignment and provide pain relief. CONCLUSION: This systematic review proposes a treatment algorithm that is comprehensive and practical to apply for the management of MWD.

Outcomes of Tibiotalocalcaneal Arthrodesis vs Talar Body Prosthesis as Treatment of Collapsed Avascular Necrosis of the Talus: A 10- to 13-Year-Follow-up Retrospective Comparative Study.

BACKGROUND: Joint salvage surgeries such as tibiotalocalcaneal arthrodesis and talar prosthesis are commonly used in the surgical treatment of collapsed avascular necrosis of the talus (AVNT). However, differences in outcomes of these 2 surgical treatments are still inconclusive. This study compared the 10- to 13-year outcomes and 10-year survivorship rates of tibiotalocalcaneal arthrodesis and talar body prosthesis in the surgical treatment of collapsed AVNT. METHODS: A retrospective comparative study was conducted of patients who underwent either tibiotalocalcaneal arthrodesis or talar body prosthesis implantation between 2005 and 2012. The demographic matching process resulted in 24 patients per treatment group. Clinical outcomes were evaluated using a numeric rating scale (NRS) of 2 hours of activities of daily living (ADL) and Foot and Ankle Ability Measure (FAAM) for ADL. Radiographic assessments included the incidence of nonunion, adjacent joint arthritis, and prosthesis loosening. The 10-year survivorship of both surgical treatments was calculated. A P value of less than .05 was considered statistically significant. RESULTS: The median NRS of 2 hours of ADL and FAAM score for ADL were statistically significantly better in the talar body prosthesis group, with P values of .001 and <.001, respectively. The statistically significant differences in FAAM score for ADL exceeded the minimum clinically important difference. In the tibiotalocalcaneal arthrodesis group, nonunion was observed in 7 of 24 patients (29.2%). No prosthesis loosening was reported in the talar body prosthesis group. The 10-year survivorship was statistically significantly higher in talar body prosthesis than tibiotalocalcaneal arthrodesis (95.8% vs 70.8%), P = .023. CONCLUSION: Talar body prosthesis implantation in selected eligible patients demonstrated statistically significantly better 10- to 13-year clinical outcomes and higher 10-year survivorship compared with tibiotalocalcaneal arthrodesis in the surgical treatment of collapsed AVNT. LEVEL OF EVIDENCE: Level III, retrospective cohort comparative study.

Critical three-dimensional factors affecting outcome in osteochondral lesion of the talus.

PURPOSE: This study aimed to investigate the relationship between clinical outcomes, patient demographics and the 3D-geometric profiles of the osteochondral lesion of the talus (OLT) following arthroscopic debridement and bone marrow stimulation. METHODS: Between 2005 and 2011, arthroscopic debridement and bone marrow stimulation were performed on 50 ankles with OLT mean age of 36.0 (19.1) years and mean follow-up time of 35.5 (20.2) months. Clinical data were assessed using validated Japanese Society of Surgery of the Foot scoring. An outcome was deemed unsatisfactory if the JSSF score was less than 80. Magnetic resonance imaging and X-rays were used to assess the 3D-geometric profiles of the OLT. RESULTS: The mean preoperative and postoperative scores were 73.4 (13.6) and 89.6 (11.5), respectively (p < 0.001). Unsatisfactory outcomes were identified in 12 % of patients. Linear regression analyses showed that lesion depth and patient age were significantly negatively correlated with postoperative scores (p < 0.001). High prognostic significances were attributed to defect depth and age of patient, and cut-off values of 7.8 mm and 80 years, respectively, were recommended to avoid a postoperative score less than 80. No significant correlations between poor clinical outcome and the other lesion profiles or demographic factors were identified. CONCLUSION: Using 3D-geometric and demographic profiles, defect depth and age of patient are essential prognostic factors in OLT and may act as a basis for preoperative surgical decisions. A lesion depth ≥ 7.8 mm and age ≥ 80 years predict an unsatisfactory outcome following arthroscopic debridement and bone marrow stimulation.

Minimally invasive distal linear metatarsal osteotomy for correction of hallux valgus: a preliminary study of clinical outcome and analytical radiographic results via a mapping system.

PURPOSES: To date, actual results of a minimally invasive distal linear metatarsal osteotomy (DLMO) via more explicit radiographic delineation are poorly understood and radiographic findings and clinical results have not been systematically correlated. Purposes of this study were (1) to evaluate the effectiveness of DLMO using a precise radiographic mapping system; and (2) to determine the relationship between radiographic outcomes and clinical results. MATERIALS AND METHODS: In 2008-2011, DLMO was performed in 30 patients (36 feet) who had reducible symptomatic hallux valgus. Clinical data were assessed using American Orthopaedic Foot and Ankle Society (AOFAS) score. Radiographs were reviewed at preoperative and final follow-up for delineations of first ray construct, hallux valgus angle (HVA), intermetatarsal angle (IMA), distal metatarsal articular angle, and other radiographic profiles. Correlation between postoperative AOFAS score and degree of malalignment was also analyzed. RESULTS: A total of 36 feet had predominantly moderate hallux valgus (26 feet with HVA: 21-39°; 23 feet with IMA: 12-17°). Mean preoperative and postoperative AOFAS scores were 70.2 ± 11.3 and 95 ± 6.4, respectively (p < 0.001). Mapping system revealed improvements of first ray construct deformity (p < 0.05). Significant reductions in all angular measurements were observed at final follow-up period (p < 0.001) and correlated significantly with changes in AOFAS score (p < 0.001). Nine feet (25 %) were observed with recurrence of deformity which showed HVA >15°. Significant sesamoid lateralization was observed (p < 0.05). Twenty-four feet (66.7 %) showing overall sagittal malunions were found with significant plantar angulation (p = 0.026) and non-significant plantar displacement compared with preoperative reference (p = 0.43). These radiographic abnormalities were not related to clinical outcomes including postoperative AOFAS scores (p > 0.05). CONCLUSION: DLMO is an acceptable procedure to correct reducible hallux valgus in most patients with moderate level of severity. Sagittal malunion, recurrence, and sesamoid lateralization are possibly radiographic abnormalities but are not associated with clinical impairments.

Outcomes and quality of life after platelet-rich plasma therapy in patients with recalcitrant hindfoot and ankle diseases: a preliminary report of 12 patients.

The present study aimed to determine the outcomes and quality of life after platelet-rich plasma therapy in patients with chronic recalcitrant diseases of the hindfoot and ankle and to identify the crucial clinical variables. The records of 12 adult patients with diseases of the hindfoot and ankle were included in the present study. These patients had been treated with platelet-rich plasma from September 2010 to April 2011 after 3 to 6 months or more of conservative treatment had been unsuccessful. They had attended the follow-up visits, were consecutively enrolled, and retrospectively studied. A total of 3 mL of autologous platelet-rich plasma was injected under fluoroscopic or ultrasound guidance into the affected areas. All patients had been evaluated using visual analog scale foot and ankle scoring before treatment and at set intervals after treatment. According to their scores at the final follow-up visit (mean 16 months), the patients were allocated to the satisfactory (score ≥ 80; n = 8) and unsatisfactory (score < 80; n = 4) groups. The health-related quality of life was assessed using the Medical Outcomes Study short-form, 36-item survey at the final follow-up visit, because the study was retrospective, and the information was not available before treatment. The mean visual analog score at the final follow-up visit (79.71 ± 17.81) was significantly greater than the mean pretreatment score (57.89 ± 20.77; p = .002). Four patients (33%) had unsatisfactory results. The mean short-form, 36-item score for the satisfactory group (85.23 ± 11.30) was significantly greater than that (57.33 ± 12.91) of the unsatisfactory group (p = .003). No definitive factors influencing the outcome of this treatment were found. The substantial number of patients with an unsatisfactory outcome indicates that platelet-rich plasma injection might be an option but might not be a mainstay of nonoperative treatment of problematic conditions of the hindfoot and ankle. The actual benefit of this treatment, including the factors influencing its outcome, are still inconclusive.

A systematic review of intermediate-term outcomes and failure rates for total ankle replacements: an Asian perspective.

BACKGROUND: There are few records for total ankle replacement (TAR) in Asia. We aimed to report the cumulative intermediate-term outcomes in terms of clinical scores, survivorship and failure rates for patients managed with TAR in Asia. METHODS: We conducted a systematic search for relevant articles published in English and other languages between January 1990 and February 2012. The study published before 1990 and used outdated prosthesis designs implanted before the early 1980s was excluded. Eligible studies were evaluated using the Coleman Methodology Score and data collection was independently performed by three reviewers. RESULTS: Seven studies qualified for analysis, describing 321 implants (112 HINTEGRA(®), 104 TNK, 35 STAR, 13 ND-Bioceram, 57 un-reported implants). Overall studies showed the improvement of clinical scores following TAR. Pooled data for the survivorship analysis ranged from 100% at 3.2 years to 77% at 14.1 years. Pooled mean failure rate was 4.9±3.2% over a mean follow-up of 5.2±1.7 years. CONCLUSIONS: TAR prostheses currently used in Asia achieved satisfactory intermediate-term outcomes in terms of clinical scores, survivorship and failure rates.

The Impacts of COVID-19 on the Management of Ankle Fractures and their Outcomes: A Systematic Review.

The COVID-19 pandemic is still an unresolved situation in Thailand and worldwide at large. The purpose of this study was to interpret the impacts of COVID-19 on the management of ankle fractures and their outcomes. A systematic search and review were performed in accordance with the PRISMA guideline based on the PubMed database. The search terms were 'ankle fracture' and 'COVID'. From an initial search, a total of 29 abstracts were found and screened in accordance with the eligibility criteria. Then, five articles were considered eligible papers for further review. This review investigated a total of 16,813 patients with ankle fractures, including 215 patients (1.27%) who were also COVID-19-positive. According to our results, the incidence of ankle fractures showed a decrease during the pandemic. However, COVID-positive ankle fracture patients demonstrated a higher prevalence of comorbidities, including chronic kidney disease, diabetes, hypertension, and obesity. COVID-19 infection was a factor that delayed the operation and increased the length of hospital stay and adverse effects from the surgery. COVID-19 infection affected the management of ankle fractures and their outcomes in terms of negative impacts such as delayed operation, increased length of hospital stay, and increased adverse effects from the surgery. Outpatient surgery was recommended to solve some of these problems.

Artificial intelligence assistance in deciding management strategies for polytrauma and trauma patients.

<b><br>Introduction:</b> Artificial intelligence (AI) is an emerging technology with vast potential for use in several fields of medicine. However, little is known about the application of AI in treatment decisions for patients with polytrauma. In this systematic review, we investigated the benefits and performance of AI in predicting the management of patients with polytrauma and trauma.</br> <b><br>Methods:</b> This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were extracted from the PubMed and Google Scholar databases from their inception until November 2022, using the search terms "Artificial intelligence," "polytrauma," and "decision." Seventeen articles were identified and screened for eligibility. Animal studies, review articles, systematic reviews, meta-analyses, and studies that did not involve polytrauma or severe trauma management decisions were excluded. Eight studies were eligible for final review.</br> <b><br>Results:</b> Eight studies focusing on patients with trauma, including two on military trauma, were included. The AI applications were mainly implemented for predictions and/or decisions on shock, bleeding, and blood transfusion. Few studies predicted death/survival. The identification of trauma patients using AI was proposed in a previous study. The overall performance of AI was good (six studies), excellent (one study), and acceptable (one study).</br> <b><br>Discussion:</b> AI demonstrated satisfactory performance in decision-making and management prediction in patients with polytrauma/severe trauma, especially in situations of shock/bleeding.</br> <b><br>Importance:</b> The present study serves as a basis for further research to develop practical AI applications for the management of patients with trauma.</br>.