Detalhe da pesquisa
1.
The RSK family of kinases: emerging roles in cellular signalling.
Nat Rev Mol Cell Biol
; 9(10): 747-58, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18813292
2.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.
Bioorg Med Chem
; 28(23): 115815, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33091850
3.
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Bioorg Med Chem
; 26(4): 913-924, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29398441
4.
Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.
PLoS Genet
; 9(9): e1003749, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24086144
5.
A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry.
Proc Natl Acad Sci U S A
; 106(28): 11606-11, 2009 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19564600
6.
A pharmacokinetic-pharmacodynamic model for the MET tyrosine kinase inhibitor, savolitinib, to explore target inhibition requirements for anti-tumour activity.
Br J Pharmacol
; 178(3): 600-613, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33125717
7.
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer.
Sci Transl Med
; 13(609): eabb3738, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516823
8.
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST.
Clin Cancer Res
; 26(14): 3751-3759, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32220888
9.
SHISA3, an antagonist of the Wnt/ß-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer.
PLoS One
; 15(7): e0236192, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32692756
10.
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Sci Transl Med
; 12(541)2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350132
11.
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma.
J Med Chem
; 62(21): 9918-9930, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31622099
12.
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
Curr Biol
; 15(19): 1762-7, 2005 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16213824
13.
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J Med Chem
; 61(19): 8797-8810, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30204441
14.
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J Med Chem
; 60(24): 10071-10091, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29172502
15.
The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.
Clin Cancer Res
; 22(22): 5527-5538, 2016 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780853
16.
Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
J Med Chem
; 59(10): 4948-64, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144831
17.
Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius.
Nat Commun
; 6: 8163, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26348592
18.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin Cancer Res
; 20(22): 5745-5755, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25239608
19.
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues.
FEBS Lett
; 586(19): 3471-6, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22967899
20.
Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen.
Chem Biol Drug Des
; 78(6): 999-1005, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22034911