Detalhe da pesquisa
1.
The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33888588
2.
Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2's functional regulation.
Hum Mutat
; 41(6): 1171-1182, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32112654
3.
Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase.
J Chem Inf Model
; 60(6): 3157-3171, 2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32395997
4.
Clinical and functional characterization of two novel ZBTB20 mutations causing Primrose syndrome.
Hum Mutat
; 39(7): 959-964, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29737001
5.
Mutations Impairing GSK3-Mediated MAF Phosphorylation Cause Cataract, Deafness, Intellectual Disability, Seizures, and a Down Syndrome-like Facies.
Am J Hum Genet
; 96(5): 816-25, 2015 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25865493
6.
Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.
Hum Mutat
; 38(4): 451-459, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28074573
7.
Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor.
Biomacromolecules
; 15(8): 3083-92, 2014 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25029480
8.
Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central ß-sheet.
Comput Struct Biotechnol J
; 23: 1169-1180, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38510972
9.
Revealing Allostery in PTPN11 SH2 Domains from MD Simulations.
Methods Mol Biol
; 2705: 59-75, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37668969
10.
Atomistic ensemble of active SHP2 phosphatase.
Commun Biol
; 6(1): 1289, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38129686
11.
Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains.
Chem Sci
; 14(21): 5743-5755, 2023 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37265738
12.
Structure of the lipodepsipeptide syringomycin E in phospholipids and sodium dodecylsulphate micelle studied by circular dichroism, NMR spectroscopy and molecular dynamics.
Biochim Biophys Acta
; 1808(9): 2102-10, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21658366
13.
Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases.
Comput Struct Biotechnol J
; 20: 989-1001, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35242289
14.
Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
ACS Chem Biol
; 17(8): 2099-2108, 2022 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35797699
15.
The effects of the L29F mutation on the ligand migration kinetics in crystallized myoglobin as revealed by molecular dynamics simulations.
Proteins
; 79(3): 867-79, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21287618
16.
Combining crystallography and molecular dynamics: the case of Schistosoma mansoni phospholipid glutathione peroxidase.
Proteins
; 78(2): 259-70, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19714775
17.
Dynamic investigation of protein metal active sites: interplay of XANES and molecular dynamics simulations.
J Am Chem Soc
; 132(42): 14901-9, 2010 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20919711
18.
An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase.
Sci Rep
; 10(1): 18530, 2020 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33116231
19.
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Sci Rep
; 9(1): 5326, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926858
20.
The kinetics of ligand migration in crystallized myoglobin as revealed by molecular dynamics simulations.
Biophys J
; 94(11): 4277-81, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18310235