Evaluation of the screw tent-pole technique for the repair of anterior maxilla width defects: a prospective, randomized, split-mouth study.

The aim of this prospective study was to compare horizontal bone augmentation in the anterior maxilla associated with two types of tenting screw used in the screw tent-pole technique. Ten patients with a premaxilla width deficiency underwent grafting with protein-free xenograft bone. A split-mouth design was used, with sides allocated randomly to receive standard and wide-head tenting screws. Implants were installed after 9 months. Patients underwent clinical, cone beam computed tomography (CBCT), and histomorphometric evaluations. The buccal aspect of the ridge was classified as flat or concave in shape. Clinical measurements showed width augmentation of 1.05mm, 2.45mm, and 2.70mm for standard screws and 1.50mm, 3.10mm, and 3.45mm for wide-head screws, at the ridge, 5mm, and 10mm, respectively. CBCT showed width augmentation of 0.74mm, 3.88mm, and 4.72mm for standard screws and 0.91mm, 4.05mm, and 4.37mm for wide-head screws, at the crest, 5mm, and 10mm, respectively. Histomorphometric analysis showed 30.99% ± 26.43% vital bone tissue, 11.32% ± 9.68% graft residue, and 57.66% ± 21.85% connective tissue for standard screws and 32.64% ± 20.28%, 9.73% ± 5.82%, and 57.61% ± 20.15%, respectively, for wide-head screws. Flat alveolar ridges showed the lowest percentage of vital bone. New bone formation seems to be optimized on concave ridges. There was no statistically significant difference in bone gain results between standard and wide-head tenting screws.

Comprehensive analysis by liquid chromatography Q-Orbitrap mass spectrometry: Fast screening of peptides and organic molecules.

The number of substances nominally listed in the prohibited list of the World Anti-Doping Agency increases each year. Moreover, many of these substances do not have a single analytical target and must be monitored through different metabolites, artifacts, degradation products, or biomarkers. A new analytical method was developed and validated for the simultaneous analysis of peptides and organic molecules using a single sample preparation and LC-Q-HRMS detection. The simultaneous analysis of 450 target molecules was performed after cleanup on a mixed-mode solid-phase extraction cartridge, combined with untreated urine. The cleanup solvent and reconstitution solvent were the most important parameters for achieving a comprehensive sample preparation approach. A fast chromatographic run based on a multistep gradient was optimized under different flows; the detection of all substances without isomeric coelution was achieved in 11 minutes, and the chromatographic resolution was considered a critical parameter, even in high-resolution mass spectrometry detection. The mass spectrometer was set to operate by switching between positive and negative ionization mode for FULL-MS, all-ion fragmentation, and FULL-MS/MS2 . The suitable parameters for the curved linear trap (c-trap) conditions were determined and found to be the most important factors for the development of the method. Only FULL-MS/MS2 enables the detection of steroids and peptides at concentrations lower than the minimum required performance levels set by World Anti-Doping Agency (1 ng mL-1 ). The combination of the maximum injection time of the ions into the c-trap, multiplexing experiments, and loop count under optimized conditions enabled the method to be applied to over 10 000 samples in only 2 months during the 2016 Rio Summer Olympic and Paralympic Games. The procedure details all aspects, from sample preparation to mass spectrometry detection. FULL-MS data acquisition is performed in positive and negative ion mode simultaneously and can be applied to untargeted approaches.

Morphological and morphometric study of the mental foramen on the M-CP-18 Jiachenjiang point / Estudio morfológico y morfométrico del foramen mental en el punto M-CP-18 Jiachenjiang

The purpose of this work was to study the morphology and morphometry of the mental foramen (MF), as well as to evaluate its morphological configuration; in addition to taking measures of its localization using as a parameter the distances of the foramen to the inferior border of the mandible and at the alveolar ridge. 80 dry mandibles were analyzed using the test of Qui-square and T test, with 5 percent of significance. Its average distance, on the right side, at the inferior edge of the mandible (IEM) was of 12.96( +/-1 .57) mm and of the alveolar ridge (AR) was of 12.82(+/-3.4) mm. On the left side it was found distant of IEM 12.96(+/-1.32) mm and of the AR 12.82(+/- 3.22)mm. The largest horizontal diameter found was of 3.32 (+/- 0.91) mm to the right and 3.25 (+/- 0.86) mm to the left side while the largest vertical diameter was of 2.38 (+/- 0.63) mm on the right and of 2.39 (+/- 0.58) mm on the left side. It was predominantly found in the oval form, on the right side, of which 98.3 percent presented as a larger diameter the horizontal (type I). On the left side, all the oval foramens were classified as of type I. 76 (95 percent) appeared single on both sides. As to the localization related to the mandibular dentition, it was localized in similar statistic proportions between the 1st and 2nd premolars and above the 2nd premolar, in 45.17 percent of the mandibles, on the right side. On the left side it was predominantly found between the 1st and 2nd premolars 48.48 percent of the mandibles. The study of the MF is of vital importance to the acupuncture practice, as well as to modern surgical procedures, like anesthesia, requiring a detailed and precise study of the morphology and morphometry of the area.

El objetivo de este trabajo fue estudiar la morfología y morfometría del foramen mentoniano (FM), así como evaluar su configuración morfológica; tomar las medidas de su localization usando como parámetro la distancia del foramen hacia el borde inferior de la mandíbula y el reborde alveolar. 80 mandíbulas secas se analizaron mediante la prueba de Chi-cuadrado y prueba t, con un 5 por ciento de significancia. Su distancia media, en el lado derecho, hasta el borde inferior de la mandíbula (BIM) fue de 12,96 (+/- 1,57) mm y del reborde alveolar (RA) fue de 12,82 (+/- 3,4) mm. En el lado izquierdo se encuentro una distancia del BIM de 12,96 (+/- 1,32) mm y del RA de 12,82 (+/- 3,22) mm. El mayor diámetro horizontal encontrado fue de 3,32 (+/- 0,91) mm a la derecha y 3,25 (+/- 0,86) mm a la izquierda, mientras que el mayor diámetro vertical fue de 2,38 (+/- 0,63) mm a la derecha y de 2,39 (+/- 0,58) mm en el lado izquierdo. Se encuentra principalmente en forma oval en el lado derecho, de los cuales 98,3 por ciento presenta un diámetro mayor horizontal (tipo I). En el lado izquierdo, todos los forámenes ovales fueron clasificados como de tipo I. 76 (95 por ciento) aparecieron solamente en ambos lados. En cuanto a la localization en relación con la dentición mandibular, fue localizado en la misma proporción estadística entre el 1er y 2d° premolar y por encima del 2ª premolar en el 45,17 por ciento de las mandíbulas en el lado derecho. En el lado izquierdo se encuentran principalmente entre los l ros y 2ros premolares en el 48,48 por ciento de las mandíbulas. El estudio del FM, es de vital importancia para la práctica de la acupuntura, así como para los modernos procedimientos quirúrgicos, como la anestesia, que requieren un estudio detallado y preciso de la morfología y morfometría de la zona.