Detalhe da pesquisa
1.
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Proc Natl Acad Sci U S A
; 119(15): e2109617119, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35353605
2.
History of Parkinson's Disease-Associated Gene, Parkin: Research over a Quarter Century in Quest of Finding the Physiological Substrate.
Int J Mol Sci
; 24(23)2023 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069057
3.
ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein.
Int J Mol Sci
; 24(2)2023 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36675288
4.
Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination.
Int J Mol Sci
; 24(10)2023 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37240373
5.
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.
Int J Mol Sci
; 22(24)2021 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34948195
6.
Retraction Notice to: Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.
Mol Ther
; 2024 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38608700
7.
Retraction Notice to: Corrigendum to "Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders".
Mol Ther
; 2024 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38608701
8.
Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.
Mol Ther
; 24(4): 746-58, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700614
9.
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.
Mov Disord
; 31(10): 1535-1542, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27548849
10.
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.
Neurobiol Dis
; 74: 89-101, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449909
11.
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Neurobiol Dis
; 79: 81-99, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937088
12.
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro.
Neurobiol Dis
; 63: 1-11, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269733
13.
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
J Biol Chem
; 287(19): 15345-64, 2012 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315227
14.
Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease.
Nutrients
; 16(1)2023 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38201915
15.
Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.
Acta Neuropathol
; 123(5): 653-69, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361813
16.
Baicalein inhibits formation of α-synuclein oligomers within living cells and prevents Aß peptide fibrillation and oligomerisation.
Chembiochem
; 12(4): 615-24, 2011 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21271629
17.
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.
Mov Disord
; 26(8): 1428-35, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21469206
18.
Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein.
Neurotoxicology
; 84: 41-52, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549656
19.
Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson's Disease.
Biomolecules
; 10(11)2020 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33172035
20.
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
BMC Complement Med Ther
; 20(1): 73, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32143619