Detalhe da pesquisa
1.
Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
Biochemistry
; 60(47): 3621-3632, 2021 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34780697
2.
Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies.
Biochemistry
; 59(14): 1428-1441, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32207968
3.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 113(31): E4523-30, 2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432954
4.
The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.
Biochemistry
; 57(24): 3387-3401, 2018 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29684272
5.
Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.
J Biol Chem
; 289(48): 33456-68, 2014 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25301950
6.
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.
ACS Med Chem Lett
; 15(5): 583-589, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746885
7.
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
J Med Chem
; 67(7): 5538-5566, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38513086
8.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
J Med Chem
; 67(6): 4541-4559, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38466661
9.
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.
Nat Struct Mol Biol
; 13(5): 408-13, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648861
10.
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.
J Med Chem
; 64(10): 6814-6826, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33900758
11.
Mycobacterium tuberculosis Decaprenylphosphoryl-ß-d-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity.
J Med Chem
; 63(5): 2557-2576, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31922409
12.
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.
Cell Chem Biol
; 27(1): 41-46.e17, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786184
13.
Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Biochemistry
; 48(9): 1996-2004, 2009 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19166329
14.
Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis.
Biochemistry
; 47(24): 6499-507, 2008 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18500821
15.
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.
Neurosci Lett
; 673: 44-50, 2018 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29499308
16.
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
Sci Rep
; 8(1): 13473, 2018 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194385
17.
Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.
J Med Chem
; 61(24): 11221-11249, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500189
18.
Flavoprotein disulfide reductases: advances in chemistry and function.
Prog Nucleic Acid Res Mol Biol
; 78: 89-142, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210329
19.
Identification of KasA as the cellular target of an anti-tubercular scaffold.
Nat Commun
; 7: 12581, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27581223
20.
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-ß-d-ribose Oxidase.
ACS Infect Dis
; 1(12): 615-26, 2015 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623058