RESUMO
This study investigated the wettability and consistency of various endodontic sealers, both inorganic and organic, and evaluated their sealing ability of root canals using the single-cone obturation technique, with and without ethylenediaminetetraacetic acid (EDTA) treatment. Bovine root canals were endodontically prepared and filled in preparation for the dye penetration test with toluidine blue solution. All sealers exhibited contact angles similar to or lower than dentin and displayed superior consistency. Among the sealers, organic sealers used without EDTA treatment showed reduced dye penetration compared to inorganic sealers. However, some inorganic and organic sealers showed dye penetration in the sealer and dentin of root canals subjected to EDTA treatment. In conclusion, the single-cone obturation technique, combined with these endodontic sealers, achieved close contact with root canal dentin due to their wettability and consistency. However, the sealing ability of certain sealers was influenced by EDTA treatment.
Assuntos
Ácido Edético , Teste de Materiais , Materiais Restauradores do Canal Radicular , Obturação do Canal Radicular , Molhabilidade , Materiais Restauradores do Canal Radicular/química , Animais , Bovinos , Obturação do Canal Radicular/métodos , Combinação de Medicamentos , Infiltração Dentária , Cavidade Pulpar , Silicatos/química , Propriedades de Superfície , Compostos de Cálcio/química , Resinas Epóxi/química , Colagem Dentária/métodos , Compostos de Alumínio/química , Técnicas In Vitro , Óxidos/química , Hidróxido de Cálcio/química , Preparo de Canal Radicular/métodos , Guta-Percha/química , Dentina/efeitos dos fármacos , CorantesRESUMO
The Phe-incorporated cyclic peptide [cyclo(-Phe1-oxazoline2-d-Val3-thiazole4-Ile5-oxazoline6-d-Val7-thiazole8-)] is in a conformational equilibrium between square and folded forms in solution. In the folded form, a CHâ¯π interaction between the Phe1 aromatic ring and the Oxz2 methyl group is observed. We endeavored to control the local conformation and thus modulate the CHâ¯π interaction and flexibility of the Phe1 side chain by controlling the electronic substituent effects at the 4-position of the aromatic ring of the Phe1 residue. The effect of the 4-substituent on the global conformation was indicated by the linear relationship between the conformational free energies (ΔGo) determined through NMR-based quantification and the Hammett constants (σ). Electron-donating substituents, which had relatively strong CHâ¯π interactions, promoted peptide folding by restraining the loss in entropy. Local control by the 4-substituent effects suggested that the Phe side chain exerts an entropic influence on the folding of these cyclic peptides.