Detalhe da pesquisa
1.
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aß prions.
Proc Natl Acad Sci U S A
; 120(13): e2220984120, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36952379
2.
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115402
3.
Phenotypic diversity in ALS and the role of poly-conformational protein misfolding.
Acta Neuropathol
; 142(1): 41-55, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32930869
4.
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.
J Virol
; 92(18)2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29976670
5.
Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding.
J Biol Chem
; 292(47): 19366-19380, 2017 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28974578
6.
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.
J Virol
; 91(2)2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27852849
7.
Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.
J Neurochem
; 140(1): 140-150, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27727458
8.
Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.
Hum Mol Genet
; 24(4): 1019-35, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305079
9.
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.
Proc Natl Acad Sci U S A
; 111(29): 10732-7, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002524
10.
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways.
Acta Neuropathol
; 131(1): 103-14, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26650262
11.
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.
Acta Neuropathol
; 132(6): 827-840, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27704280
12.
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Mol Ther
; 23(1): 53-62, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25228069
13.
Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
J Neurochem
; 133(3): 452-64, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25557022
14.
Experimental transmissibility of mutant SOD1 motor neuron disease.
Acta Neuropathol
; 128(6): 791-803, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25262000
15.
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease.
PLoS Pathog
; 7(3): e1001317, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21437239
16.
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice.
Viruses
; 15(9)2023 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37766226
17.
Coinfecting prion strains compete for a limiting cellular resource.
J Virol
; 84(11): 5706-14, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20237082
18.
Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.
Acta Neuropathol
; 131(1): 151-4, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26541429
19.
Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates.
Neurosci Lett
; 742: 135553, 2021 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33346076
20.
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence.
Acta Neuropathol Commun
; 9(1): 92, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34016165