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Chem Biodivers ; 20(3): e202201169, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36823346

RESUMO

Type 1 diabetes is characterized by insulin deficiency due to the destruction of pancreatic ß cells, leading to hyperglycemia, which in turn induces vascular complications. In the current study, we investigated the effect of intraperitoneal administration of clove essential oil (CEO: 20 mg/kg body weight) on certain oxidative stress and glucose metabolism enzymes, as well as the expression of proinflammatory mediators. Administration of CEO to diabetic rats showed a significant decline in blood glucose levels, total cholesterol, and xanthine oxidase, compared to the streptozotocin group. Furthermore, these treated rats elicited a notable attenuation in the levels of lipid peroxides, and thiols groups in both liver and brain tissues. The activities of antioxidant and metabolic enzymes were reverted to normality in diabetic upon CEO administration. In addition to its protective effects on red blood cell hemolysis, CEO is a potent α-amylase inhibitor with an IC50 =298.0±2.75 µg/mL. Also, treatment of diabetic rats with CEO significantly reduced the iNOS expression in the spleen. Our data showed that CEO has potential beneficial effects on diabetes, which can possibly prevent the pathogenesis of diabetic micro- and macrovascular complications.


Assuntos
Diabetes Mellitus Experimental , Óleos Voláteis , Syzygium , Ratos , Animais , Óleo de Cravo/farmacologia , Óleo de Cravo/uso terapêutico , Óleos Voláteis/farmacologia , Óleos Voláteis/uso terapêutico , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Experimental/metabolismo , Mediadores da Inflamação/metabolismo , Mediadores da Inflamação/farmacologia , Estresse Oxidativo , Antioxidantes/metabolismo , Estreptozocina , Hipoglicemiantes/farmacologia
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