Detalhe da pesquisa
1.
Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.
Biochem Biophys Res Commun
; 511(3): 579-586, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30824186
2.
Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.
Molecules
; 22(4)2017 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28338621
3.
Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants.
Angew Chem Int Ed Engl
; 56(43): 13232-13236, 2017 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28834017
4.
Optimized Target Residence Time: Typeâ I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Angew Chem Int Ed Engl
; 56(19): 5363-5367, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28397331
5.
Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp3-Enriched Fragment Library.
J Med Chem
; 66(9): 6297-6314, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37130057
6.
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J Med Chem
; 65(15): 10341-10356, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35912476
7.
Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.
PLoS One
; 12(9): e0184627, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892510
8.
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.
J Med Chem
; 60(19): 8027-8054, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28834431
9.
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Sci Transl Med
; 9(394)2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28615362