Detalhe da pesquisa
1.
Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability.
Chemistry
; 26(65): 15035-15044, 2020 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633095
2.
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.
Chemistry
; 24(38): 9675-9691, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672968
3.
Selective irreversible chemical tagging of cysteine with 3-arylpropiolonitriles.
Bioconjug Chem
; 25(2): 202-6, 2014 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24410136
4.
The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives.
Chem Biol Interact
; 395: 110973, 2024 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574837
5.
No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice.
Chem Biol Interact
; 392: 110929, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38417730
6.
Dynamic micelles of mannoside glycolipids are more efficient than polymers for inhibiting HIV-1 trans-infection.
Bioconjug Chem
; 24(11): 1813-23, 2013 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24134734
7.
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.
Acc Chem Res
; 45(5): 756-66, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22360473
8.
Cobalt tris(4-vinylphenyl)corrole: out of the frying pan into the polymer.
Chem Commun (Camb)
; 59(15): 2098-2101, 2023 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36723238
9.
Synthesis of novel mannoside glycolipid conjugates for inhibition of HIV-1 trans-infection.
Bioconjug Chem
; 23(9): 1731-9, 2012 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22871093
10.
Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure.
Biomedicines
; 10(5)2022 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35625901
11.
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
J Med Chem
; 65(6): 4649-4666, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35255209
12.
Cationic cyclization of 2-alkenyl-1,3-dithiolanes: diastereoselective synthesis of trans-decalins.
J Org Chem
; 76(9): 3274-85, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21446693
13.
An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae.
ACS Chem Neurosci
; 12(15): 2865-2877, 2021 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34284583
14.
Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure.
Toxicology
; 456: 152787, 2021 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887375
15.
A HTS assay for the detection of organophosphorus nerve agent scavengers.
Chemistry
; 16(11): 3510-23, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20143367
16.
Theoretical mechanistic study of the TBD-catalyzed intramolecular aldol reaction of ketoaldehydes.
J Org Chem
; 75(14): 4728-36, 2010 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20545376
17.
Generation of Nucleophilic Chromium Acetylides from gem-Trichloroalkanes and Chromium Chloride: Synthesis of Propargyl Alcohols.
European J Org Chem
; 2010(10): 1869-1874, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21562621
18.
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.
Biomolecules
; 10(6)2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32512884
19.
Insight into the complexation mode of bis(nitrilotriacetic acid) (NTA) ligands with Ni(2+) involved in the labeling of histidine-tagged proteins.
Chemistry
; 15(46): 12689-701, 2009 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19876964
20.
Novel chiral derivatizing isothiocyanate-based agent for the enantiomeric excess determination of amines.
Chem Commun (Camb)
; (23): 3410-2, 2009 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19503887