Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
IRAL Int Rev Appl Linguist Lang Teach ; 62(3): 1213-1235, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39258277

RESUMO

The present paper seeks to explore the contextual factors shaping the emotional labour experiences of secondary school teachers and explain the ways these educators manage their emotions. Data were generated through a series of 20 in-depth, semi-structured interviews with modern language (ML) teachers in the UK. The findings showed that teachers experienced primarily negative forms of emotional labour and these experiences were driven by five interrelated contextual factors: the lack of institutional support, heavy workload, low perceived status of MLs, students' lack of motivation, and classroom misbehaviour. To manage their emotions, the study reveals that teachers used a wide range of coping mechanisms such as suppression, venting, social support, positive reframing, and the development of positive student-teacher relationships. In light of our results, we call for the emotional dimension of teaching to be better integrated into training programmes, an improvement in working conditions and better support mechanisms for teachers.

2.
Bioorg Med Chem ; 18(14): 5291-300, 2010 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-20542439

RESUMO

A series of indole, 7-azaindole, benzofuran, and benzothiophene compounds have been prepared and evaluated for affinity at D2-like dopamine receptors. These compounds share structural elements with the classical D2-like dopamine receptor antagonists haloperidol, N-methylspiperone and benperidol. Two new compounds, 4-(4-iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methyl)piperidin-4-ol (6) and 4-(4-iodophenyl)-1-((5-methoxy-1H-indol-3-yl)methyl)piperidin-4-ol (7), were found to have high affinity to and selectivity for D2 versus D3 receptors. Changing the aromatic ring system from an indole to other heteroaromatic ring systems reduced the D2 binding affinity and the D2 versus D3 selectivity.


Assuntos
Antagonistas de Dopamina/química , Antagonistas de Dopamina/farmacologia , Antagonistas dos Receptores de Dopamina D2 , Receptores de Dopamina D2/metabolismo , Adenilil Ciclases/metabolismo , Benzofuranos/síntese química , Benzofuranos/química , Benzofuranos/farmacologia , Linhagem Celular , Antagonistas de Dopamina/síntese química , Humanos , Indóis/síntese química , Indóis/química , Indóis/farmacologia , Ligação Proteica , Tiofenos/síntese química , Tiofenos/química , Tiofenos/farmacologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA