Detalhe da pesquisa
1.
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc Natl Acad Sci U S A
; 116(7): 2551-2560, 2019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683722
2.
Synaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid.
Cereb Cortex
; 30(1): 226-240, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034037
3.
A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude).
Mol Pharmacol
; 88(2): 401-20, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26056160
4.
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
J Biol Chem
; 289(13): 9304-19, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24497639
5.
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Cell Chem Biol
; 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38537632
6.
High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs.
Noncoding RNA
; 9(1)2023 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649031
7.
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.
J Immunother Cancer
; 11(11)2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37963637
8.
Targeting RAS oncogenesis with SOS1 inhibitors.
Adv Cancer Res
; 153: 169-203, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35101230
9.
Quantitative and kinetic profile of Wnt/ß-catenin signaling components during human neural progenitor cell differentiation.
Cell Mol Biol Lett
; 16(4): 515-38, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21805133
10.
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
Cell Oncol (Dordr)
; 44(3): 581-594, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33492659
11.
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
J Med Chem
; 64(17): 12723-12737, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34428039
12.
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
ChemMedChem
; 15(10): 827-832, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32237114
13.
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
J Med Chem
; 63(13): 7293-7325, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32502336
14.
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Mol Cancer Ther
; 19(1): 26-38, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582533
15.
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
J Med Chem
; 63(2): 601-612, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31859507
16.
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J Med Chem
; 63(15): 8025-8042, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32338514
17.
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.
Endocrinology
; 149(10): 4846-56, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566127
18.
A one-day, dispense-only IP-One HTRF assay for high-throughput screening of Galphaq protein-coupled receptors: towards cells as reagents.
Assay Drug Dev Technol
; 6(1): 39-53, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18315499
19.
Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks.
Front Pharmacol
; 9: 848, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30123130
20.
Improvement of impaired electrical activity in NPC1 mutant cortical neurons upon DHPG stimulation detected by micro-electrode array.
Brain Res
; 1694: 87-93, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29753706