Assuntos
Doenças Mamárias/genética , Displasia Ectodérmica Hipo-Hidrótica Autossômica Recessiva/genética , Receptor Edar/genética , Ceratodermia Palmar e Plantar/genética , Mutação de Sentido Incorreto/genética , Adolescente , Sequência de Aminoácidos , Sequência de Bases , Consanguinidade , Exoma/genética , Feminino , Humanos , Masculino , Dados de Sequência Molecular , Linhagem , Análise de Sequência de DNARESUMO
Post-kala-azar dermal leishmaniasis is a dermatosis which was described during the first quarter of this century. Most cases reported are from the Indian subcontinent and certain parts of Africa. The disease generally follows an attack of kala-azar, usually a few months to several years after the visceral disease has healed. The clinical picture is variable. In this report, we present a case of post-kala-azar dermal leishmaniasis in a 5-year-old Iranian boy who presented with multiple, asymptomatic, erythematous papules on his trunk and extremities and a brownish, figurate discoloration on his lower extremities, 4 years after an attack of kala-azar which was completely cured. Histopathological examination of one of the biopsied papules revealed multiple Leishman bodies. The patient was successfully treated with a pentavalent antimonial compound.
Assuntos
Leishmaniose Tegumentar Difusa/etiologia , Leishmaniose Tegumentar Difusa/patologia , Leishmaniose Visceral/complicações , Antiprotozoários/administração & dosagem , Biópsia por Agulha , Pré-Escolar , Humanos , Irã (Geográfico) , Leishmaniose Tegumentar Difusa/tratamento farmacológico , Leishmaniose Visceral/diagnóstico , Masculino , Meglumina/administração & dosagem , Antimoniato de Meglumina , Compostos Organometálicos/administração & dosagemRESUMO
BACKGROUND: Epidemiology of Cutaneous Leishmaniasis in Hormozgan province during April 1994 to March 1998 was studied. METHODS: Data were collected from the Health service Centres throughout the province as well as from dermatologists. The patients were diagnosed clinically or paraclinically and all important details were recorded on specially designed forms. RESULTS: A total of 4094 patients with 7255 lesions were diagnosed. 42.24% of the sufferers were under 20 years and 6.47% were over 40 years old. 52.10% of the patients had one lesion and 33.98% had two lesions. Most of the cases were seen during January to March. The incidence rate per 10000 ranged from 5.90 in 1998 to 16.98 in 1996. CONCLUSIONS: A decreasing trend in the number of cases after 1996 may be due to the awareness of local health authorities, preventative activities and education.