RESUMO
INTRODUCTION: Infectious diseases are a frequent cause of morbidity among British troops. The aim of this paper is to describe the spectrum of infectious diseases seen when UK service personnel are evacuated for definitive care to the Role 4 Medical Treatment Facility based at Birmingham Heartlands Hospital. METHOD: A retrospective analysis of all military patients presenting with infectious diseases and treated at Birmingham Heartlands Hospital between 14 April 2005 and 31 December 2013 was undertaken. RESULTS: During this period, 502 patients were identified. Infections originated in 49 countries, most commonly Afghanistan (46% cases), the UK (10% cases) and Belize (9% of cases). The most common presentations were dermatological conditions, gastroenterological illnesses and undifferentiated fevers. CONCLUSION: UK service personnel in significant numbers continue to suffer a wide range of infectious diseases, acquired throughout the globe, which often require specialist tertiary infection services to diagnose and manage. Future prospective data collection is recommended to identify trends, which in turn will inform military training needs and future research priorities in the Defence Medical Services (DMS) and allows development of appropriate policies and clinical guidelines for management of DMS personnel with infectious diseases.
Assuntos
Infecções/epidemiologia , Militares/estatística & dados numéricos , Adolescente , Adulto , Assistência Ambulatorial/tendências , Feminino , Custos de Cuidados de Saúde , Hospitalização/tendências , Hospitais Militares/estatística & dados numéricos , Humanos , Infecções/microbiologia , Infecções/parasitologia , Masculino , Pessoa de Meia-Idade , Qualidade da Assistência à Saúde , Estudos Retrospectivos , Licença Médica/estatística & dados numéricos , Reino Unido/epidemiologia , Adulto JovemRESUMO
Multiplex PCR can provide rapid diagnosis for patients presenting with an acute undifferentiated febrile illness. Such technology is useful in deployed settings, where access to conventional microbiological diagnosis is limited. It was used in Sierra Leone to guide management of febrile healthcare workers, in whom Ebola virus disease was a possible cause. In particular, it informed appropriate antibiotic treatment while minimising the risk to clinicians of exposure to the causative organism.
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Febre/diagnóstico , Febre/microbiologia , Gastroenterite/diagnóstico , Gastroenterite/microbiologia , Doença pelo Vírus Ebola/terapia , Adulto , Surtos de Doenças , Gastroenterite/complicações , Pessoal de Saúde , Humanos , Masculino , Reação em Cadeia da Polimerase MultiplexRESUMO
Cutaneous myiasis is a well-described problem in travellers to endemic regions including military personnel. Realistic training is important to ensure that healthcare workers have the confidence and expertise to recognise cutaneous myiasis and safely remove larvae if required. A model is described here that is simple, reproducible and realistic, and will allow for training of military healthcare workers in safe surgical removal of larvae when required.
Assuntos
Educação Médica/métodos , Medicina Militar/educação , Modelos Biológicos , Miíase/parasitologia , Miíase/cirurgia , Animais , Humanos , Larva , Carne/parasitologia , SuínosRESUMO
Enteric fever (typhoid and paratyphoid) remains a threat to British troops overseas and causes significant morbidity and mortality. We report the case of a soldier who developed typhoid despite appropriate vaccination and field hygiene measures, which began 23â days after returning from a deployment in Sierra Leone. The incubation period was longer than average, symptoms started 2â days after stopping doxycycline for malaria chemoprophylaxis and initial blood cultures were negative. The Salmonella enterica serovar Typhi eventually isolated was resistant to amoxicillin, co-amoxiclav, co-trimoxazole and nalidixic acid and had reduced susceptibility to ciprofloxacin. He was successfully treated with ceftriaxone followed by azithromycin, but 1â month later he remained fatigued and unable to work. The clinical and laboratory features of enteric fever are non-specific and the diagnosis should be considered in troops returning from an endemic area with a febrile illness. Multiple blood cultures and referral to a specialist unit may be required.
Assuntos
Militares , Febre Tifoide/diagnóstico , Adulto , Antibacterianos/uso terapêutico , Azitromicina/uso terapêutico , Ceco/diagnóstico por imagem , Ceftriaxona/uso terapêutico , Humanos , Doenças Linfáticas/diagnóstico por imagem , Masculino , Mesentério/diagnóstico por imagem , Serra Leoa , Tomografia Computadorizada por Raios X , Falha de Tratamento , Febre Tifoide/tratamento farmacológico , Febre Tifoide/prevenção & controle , Vacinas Tíficas-Paratíficas/uso terapêutico , Reino UnidoRESUMO
Undifferentiated febrile illness in a returning soldier is a common problem encountered by serving medical officers. A 32-year-old soldier presented to Birmingham Heartlands Hospital with fever and acute kidney injury after return from Borneo. Leptospirosis was suspected and empirical antibiotics were started before subsequent confirmation by serology and PCR. Leptospirosis is common in South-East Asia, and troops exercising in jungle areas, and in the UK, are at risk. Advice, including inpatient management when appropriate, is available from the UK Role 4 Military Infectious Diseases and Tropical Medicine Service.
Assuntos
Leptospirose/diagnóstico , Militares , Viagem , Injúria Renal Aguda/etiologia , Adulto , Antibacterianos/uso terapêutico , Bornéu , Ceftriaxona/uso terapêutico , DNA Bacteriano/sangue , Diarreia/etiologia , Doxiciclina/uso terapêutico , Febre/etiologia , Humanos , Imunoglobulina M/imunologia , Leptospira/genética , Leptospirose/complicações , Leptospirose/tratamento farmacológico , Leptospirose/imunologia , Masculino , Mialgia/etiologia , Reação em Cadeia da Polimerase , Testes Sorológicos , Reino UnidoRESUMO
Leishmaniasis is an infectious disease caused by Leishmania protozoa, transmitted by the bite of phlebotomine sandflies. It causes a spectrum of clinical syndromes, of which the most common are cutaneous and visceral leishmaniasis. Clinical presentation is highly variable and is dependent on multiple factors, such as Leishmania species and patient characteristics (including immune competence). The relationship between these variables is poorly understood, and there is no single, evidence-based treatment for the disease. Currently management focuses on identification of the species, but this requires specialist tests which are often unavailable, particularly on military operations. Leishmaniasis is of particular relevance to military medical personnel as it is endemic in many tropical and sub-tropical regions of the world, including Belize, Iraq and Afghanistan where UK Armed Forces may be deployed. It can present a potentially serious threat to military personnel deployed in endemic areas due to the possibility of long-term sequelae of infection.
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Leishmaniose/diagnóstico , Leishmaniose/prevenção & controle , Medicina Militar , Doenças Profissionais/diagnóstico , Doenças Profissionais/prevenção & controle , Gluconato de Antimônio e Sódio/uso terapêutico , Antiprotozoários/uso terapêutico , Diagnóstico Diferencial , Doenças Endêmicas , Humanos , Mosquiteiros Tratados com Inseticida , Leishmaniose/tratamento farmacológico , Leishmaniose/epidemiologia , Doenças Profissionais/tratamento farmacológico , Doenças Profissionais/epidemiologia , Reino UnidoRESUMO
NATO describes 'Role 4' military medical services as those provided for the definitive care of patients who cannot be treated within a theatre of operations and these are usually located in a military force's country of origin and may include the involvement of civilian medical services. The UK Defence Medical Services have a proud history of developing and providing clinical services in infectious diseases and tropical medicine, sexual health and HIV medicine, and medical microbiology and virology. These UK Role 4 Military Infection Services have adapted well to recent overseas deployments, but new challenges will arise due to current military cutbacks and a greater diversity of contingency operations in the future. Further evidence-based development of these services will require leadership by military clinicians and improved communication and support for 'reach-back' services.
Assuntos
Controle de Doenças Transmissíveis/tendências , Medicina Militar/tendências , Medicina Tropical/tendências , Controle de Doenças Transmissíveis/história , História do Século XVIII , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Medicina Militar/história , Medicina Militar/organização & administração , Infecções Sexualmente Transmissíveis/história , Infecções Sexualmente Transmissíveis/prevenção & controle , Medicina Tropical/história , Reino UnidoRESUMO
Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections are endemic in most developing countries, including Nepal and Afghanistan, and may cause outbreaks in military personnel. Previously, more than 99% of new British Gurkha recruits were already immune to HAV because of prior infection, but this may be declining due to improved living conditions in their countries of origin. Acute HAV infections have occurred in Gurkha soldiers serving in Afghanistan, which made them unfit for duty for 2-3 months. In one case, early serological diagnosis was impeded by IgM results against both HAV and HEV that were caused by cross-reactivity or persistence from a previous infection. These cases have led to a policy change whereby all Gurkha recruits are now tested for previous HAV infection and if negative they are offered vaccination. Meanwhile, HEV infection remains a significant threat in Nepal and Afghanistan with low levels of background immunity and no commercially available vaccine.
Assuntos
Anticorpos Antivirais/sangue , Vírus da Hepatite A/imunologia , Hepatite A/diagnóstico , Militares , Adulto , Campanha Afegã de 2001- , Hepatite A/etnologia , Hepatite A/prevenção & controle , Humanos , Masculino , Nepal/etnologia , Reino Unido , Adulto JovemRESUMO
Cutaneous larva migrans (CLM) is one of numerous skin diseases that occur in British military personnel on deployments to the tropics and sub-tropics. It is typically managed by military primary healthcare services, but diagnostic uncertainty or unavailability of anti-helminthic medication may prompt referral to UK Role 4 healthcare services. Cases of CLM seen at the UK Role 4 Military Infectious Diseases & Tropical Medicine Service from 2005 to 2020 were identified and their case notes were reviewed to identify learning and discussion points. There were 12 cases identified, of which five came from Brunei and three were from Belize. Causes for referral were due to diagnostic uncertainty (58%) and the unavailability of anti-helminthic medication (42%). Several cases had CLM in an unusual distribution due to specific military activities performed in endemic areas. Telemedicine was very useful in making some of the diagnoses in theatre and avoiding the need for medical evacuation. Military personnel may have unusual presentations of CLM due their unique military activities. In areas that are endemic for CLM, clinicians should maintain high clinical suspicion for CLM, carry appropriate anti-helminthic medications and consider screening cases of CLM and their colleagues for other infections with similar aetiology (eg, human hookworm infection and strongyloidiasis).
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Larva Migrans , Militares , Estrongiloidíase , Humanos , Larva Migrans/diagnóstico , Larva Migrans/tratamento farmacológico , Larva Migrans/epidemiologia , BelizeRESUMO
Leishmaniasis is an infectious disease caused by Leishmania protozoa and occurs as a spectrum of clinical syndromes ranging from various forms of cutaneous leishmaniasis (CL) to mucosal leishmaniasis (ML) and visceral leishmaniasis (VL). CL in Afghanistan is either zoonotic (ZCL) due to L. major or anthroponotic (ACL) due to L. tropica and there has been a prolonged epidemic of ACL in eastern Afghanistan since 1987. However, there have been remarkably few reports of CL due to L. tropica amongst foreign troops serving in Afghanistan since 2001. We describe two such cases in Royal Marines deployed to Oruzgan Province in Afghanistan from 2008-9. These patients illustrate important issues regarding the clinical features, referral, diagnosis, treatment and epidemiology of CL amongst foreign troops in Afghanistan. This disease has the potential to cause significant disruption to military personnel and units and so requires efficient management in order to maintain operational effectiveness.
Assuntos
Leishmania/isolamento & purificação , Leishmaniose Cutânea/diagnóstico , Militares , Pele/parasitologia , Adulto , Afeganistão/etnologia , Animais , Diagnóstico Diferencial , Doenças Endêmicas , Humanos , Leishmaniose Cutânea/etnologia , Leishmaniose Cutânea/parasitologia , Masculino , Pele/patologia , Reino Unido/epidemiologia , Adulto JovemRESUMO
We report a case of successful surgical treatment of Q fever endocarditis with mitral valve repair in a 66-year old retired British soldier. Valve replacement is invariably undertaken in Q fever endocarditis due to the degree of valvular damage and concerns about eradicating the organism, Coxiella burnetii. Our unique case allowed valve repair since pre-existing myxomatous degeneration and subsequent posterior mitral valve leaflet prolapse resulted in significant excess valve tissue, allowing quadrangular resection of the damaged and perforated P2 portion of this leaflet. Follow-up at four years (including three years of antibiotic treatment) has confirmed excellent valve repair, with no echocardiographic, clinical or microbiological evidence of recurrence. We are only the second group to describe valve repair in a patient with chronic Q fever endocarditis. Valve repair is preferable to valve replacement for Q fever endocarditis, if technically possible.
Assuntos
Endocardite Bacteriana/cirurgia , Valva Mitral/cirurgia , Febre Q/complicações , Idoso , Antibacterianos/uso terapêutico , Coxiella burnetii , Endocardite Bacteriana/tratamento farmacológico , Endocardite Bacteriana/microbiologia , Humanos , Masculino , Febre Q/microbiologiaRESUMO
OBJECTIVES: In Afghanistan zoonotic cutaneous leishmaniasis (CL) due to Leishmania major has been less widely reported than anthroponotic CL due to L. tropica. However, an outbreak of zoonotic CL occurred amongst a group of British soldiers at a military camp near Mazar-e-Sharif in the Balkh province of northern Afghanistan in 2004. METHODS: A study was performed to assess the epidemiology, clinical features, parasitology results, treatment outcomes and environmental health measures associated with this incident. RESULTS: Twenty (17%) of 120 soldiers developed CL due to L. major and the risk of infection increased with the proximity of their accommodation to an area of recently cleared scrub, where many wild rodents were observed. Most cases had features of local dissemination, including secondary lesions from the pseudo-Koebner phenomenon, sporotrichoid lymphatic spread, lymphadenopathy and satellite papules or milia formation around healing lesions. Several cases responded poorly to fluconazole and low dose (10 mg/kg) sodium stibogluconate, which were considered suitable treatments at the time. Environmental health measures at the military camp were found to be deficient. CONCLUSIONS: Zoonotic CL due to L. major is a significant threat for foreign troops based in Balkh, Afghanistan and may present with unusually severe clinical features and be resistant to previously recommended treatments.
Assuntos
Campanha Afegã de 2001- , Surtos de Doenças , Leishmania major/isolamento & purificação , Leishmaniose Cutânea/etnologia , Militares , Roedores/parasitologia , Zoonoses/epidemiologia , Adulto , Afeganistão/etnologia , Animais , Feminino , Humanos , Leishmaniose Cutânea/parasitologia , Leishmaniose Cutânea/transmissão , Masculino , Estudos Retrospectivos , Reino Unido , Zoonoses/transmissãoRESUMO
OBJECTIVES: Undifferentiated febrile illnesses have been a threat to British expeditionary forces ever since the Crusades. The infections responsible were identified during the Colonial Era, both World Wars and smaller conflicts since, but nearly all remain a significant threat today. Undiagnosed febrile illnesses have occurred amongst British troops in Helmand, Afghanistan since 2006 and so a fever study was performed to identify them. METHODS: From May to October 2008, all undifferentiated fever cases seen at the British field hospital in Helmand, Afghanistan were assessed using a standard protocol. Demographic details, clinical features and laboratory results were recorded and paired serum samples were sent for testing at the UK Special Pathogens Reference Unit (SPRU). RESULTS: Over 6 months, there were 26 cases of"Helmand Fever" assessed and 23 diagnoses were made of which 12 (52%) were sandfly fever, 6 (26%) were acute Qfever and 5 (22%) were rickettsial infections. Four cases had co-infections and 7 cases were not diagnosed (mostly due to inadequate samples). The clinical features and laboratory results available at the British field hospital did not allow these diseases to be distinguished from each other. The exact type of rickettsial infection could not be identified at SPRU. CONCLUSIONS: These cases probably represent the "tip of an iceberg" for British and Allied forces. More resources for diagnostic facilities and follow-up of patients are required to improve the management and surveillance of "Helmand Fever" cases; until then doxycycline 100 mg twice daily for 2 weeks should be given to all troops who present with an undifferentiated febrile illness in Helmand, Afghanistan. Patients with acute Q fever should be followed-up for at least 2 years to exclude chronic Q fever. Prevention of these diseases requires a better understanding of their epidemiology, but prophylaxis with doxycycline and possibly Q fever vaccine should be considered.
Assuntos
Febre/etiologia , Militares , Afeganistão , Febre/epidemiologia , Cefaleia/epidemiologia , Cefaleia/etiologia , Humanos , Doenças Musculares/epidemiologia , Doenças Musculares/etiologia , Febre por Flebótomos/diagnóstico , Febre por Flebótomos/epidemiologia , Febre Q/diagnóstico , Febre Q/epidemiologia , Infecções por Rickettsia/diagnóstico , Infecções por Rickettsia/epidemiologia , Reino UnidoRESUMO
Undifferentiated febrile illnesses present diagnostic and treatment challenges in the Firm Base, let alone in the deployed austere environment. We report a series of 14 cases from Operation TRENTON in South Sudan in 2017 that coincided with the rainy season, increased insect numbers and a Relief in Place. The majority of patients had headaches, myalgia, arthralgia and back pain, as well as leucopenia and thrombocytopenia. No diagnoses could be made in theatre, despite a sophisticated deployed laboratory being available, and further testing in the UK, including next-generation sequencing, was unable to establish an aetiology. Such illnesses are very likely to present in tropical environments, where increasing numbers of military personnel are being deployed, and clinicians must be aware of the non-specific presentation and treatment, as well as the availability of Military Infection Reachback services to assist in the management of these cases.
Assuntos
Febre , Militares , Febre/diagnóstico , Cefaleia/diagnóstico , Humanos , Sudão do Sul/epidemiologiaRESUMO
OBJECTIVES: Infectious diseases affecting British troops are mostly due to gastrointestinal and respiratory illnesses, but these are usually minor in severity, easy to manage and short in duration. To assess the importance of infections that are more severe, difficult to manage or longer in duration, it is necessary to look at military cases that are evacuated or otherwise referred to the UK Role 4 (definitive care) medical facility for infectious diseases. METHODS: Case notes from military infectious disease patients seen at Birmingham Heartlands Hospital in 2005-2009 were reviewed to extract data on demographics, origin of infection, diagnostic categories, exact diagnoses, type and duration of care, time off duty, quality of care and costs incurred. RESULTS: Over a 4-year period, 138 cases were referred, 131 (95%) were male and 98 (71%) were from the Army. The origin of infection was Afghanistan in 52 (38%) and Belize in 19 (14%). From 131 patients (95%) that attended, 59 (45%) had dermatological illnesses and 38 (29%) had undifferentiated febrile illnesses. Diagnoses included 35 (27%) with cutaneous leishmaniasis and 21 (16%) with "Helmand Fever" due to sandfly fever, acute Q fever or rickettsial infection. For 51 in-patients, the median (range) length of stay was 3 (1-17) days and time off duty was 20 (5-127) days. For 80 out-patients, the median (range) number of attendances was 1 (1-23) and time off duty was 22 (1-228) days. All cases were seen promptly (within 7 days for in-patients and 28 days for out-patients), but only 59 (45%) had appropriate letters sent to the referring medical officer and none had F Med 85 notifications of infectious disease submitted. Aeromedical evacuation costs could not be calculated, but UK hospital care cost approximately pound 78 000 per year. CONCLUSIONS: Dermatological infections and undifferentiated febrile illnesses that require management at a UK Role 4 facility are important causes of disease non-battle injury. Prospective collection of this data in the future will be a valuable asset.
Assuntos
Infecções Bacterianas/epidemiologia , Militares , Doenças Parasitárias/epidemiologia , Viroses/epidemiologia , Adolescente , Adulto , Notificação de Doenças/estatística & dados numéricos , Feminino , Febre/etiologia , Custos Hospitalares , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Garantia da Qualidade dos Cuidados de Saúde , Licença Médica/estatística & dados numéricos , Reino Unido/epidemiologia , Adulto JovemRESUMO
Tropical diseases remain a significant threat to deployed military personnel as demonstrated by recent outbreaks amongst troops in Sierra Leone, Iraq and Afghanistan. Five cases are presented from military deployments in tropical or sub-tropical areas, which illustrate important diseases and diagnostic principles for military physicians.
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Militares , Medicina Tropical , Adulto , Afeganistão , Dengue/diagnóstico , Diagnóstico Diferencial , Feminino , Febre de Causa Desconhecida/etiologia , Hepatite Viral Humana/diagnóstico , Humanos , Iraque , Masculino , Pessoa de Meia-Idade , Miíase/diagnóstico , Sarcoidose/diagnóstico , Serra Leoa , Reino UnidoAssuntos
Epidemias/história , Militares/história , Febre por Flebótomos/história , Navios/história , História do Século XX , Humanos , Militares/estatística & dados numéricos , Febre por Flebótomos/diagnóstico , Febre por Flebótomos/epidemiologia , Febre por Flebótomos/terapia , Reino Unido/epidemiologiaRESUMO
A 34-year-old female soldier presented with fever and behavioural changes while deployed in Kenya and was diagnosed with encephalitis. The patient underwent urgent aeromedical evacuation to the Queen Elizabeth Hospital, Birmingham for further management. Microbiology tests excluded common infectious causes that are endemic in the East Africa region. However, an autoantibody screen was positive for antibodies against the N-methyl-D-aspartate receptor (NMDAR). Full body imaging confirmed the presence of limbic encephalitis and an ovarian mass suggestive of a teratoma. The patient was diagnosed with ovarian teratoma-associated anti-NMDAR encephalitis, a potentially fatal disease. The patient underwent surgery to remove the teratoma and commenced immunotherapy with steroids, plasma exchange and rituximab. This case highlights the diagnostic challenges of fever with behavioural changes in military personnel deployed in a tropical environment.
Assuntos
Encefalite Antirreceptor de N-Metil-D-Aspartato , Neoplasias Ovarianas , Teratoma , Adulto , Feminino , Humanos , Quênia , Imagem Corporal TotalRESUMO
OBJECTIVES: The aim of this study was to see what lessons could be learnt from the suspected viral gastroenteritis outbreaks that have occurred in deployed British troops during 2002-7. METHOD: Epidemiological and laboratory data from identifiable outbreaks were reviewed, including epidemic curves and the results of PCR testing for enteropathic viruses. RESULTS: The epidemic curves of outbreaks varied predictably in accordance with the size of the population at risk and whether this population was constant or expanding. Of 11 outbreaks identified, 10 (91%) had a proven viral cause and 10 (91%) occurred in Iraq. Of 84 enteropathic viruses identified, 61 (73%) were noroviruses and these included both unknown strains and those that were common in the UK and Europe. Of the 10 viral outbreaks, 3 (30%) occurred in medical units, 5 (50%) were associated with large-scale relief in place (RiP) deployments and 5 (50%) involved >3 different viruses, which is strongly suggestive of food or water contamination. CONCLUSION: These findings can help to predict future viral gastroenteritis outbreaks and target improved prevention strategies appropriately. However, more systematic studies are now required.
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Surtos de Doenças , Gastroenterite/epidemiologia , Militares/estatística & dados numéricos , Infecções por Caliciviridae/epidemiologia , Gastroenterite/virologia , Humanos , Iraque/epidemiologia , Norovirus , Reino Unido/epidemiologiaRESUMO
BACKGROUND: Limited data exist describing supportive care management, laboratory abnormalities and outcomes in patients with Ebola virus disease (EVD) in West Africa. We report data which constitute the first description of the provision of enhanced EVD case management protocols in a West African setting. METHODS: Demographic, clinical and laboratory data were collected by retrospective review of clinical and laboratory records of patients with confirmed EVD admitted between 5 November 2014 and 30 June 2015. RESULTS: A total of 44 EVD patients were admitted (median age 37 years (range 17-63), 32/44 healthcare workers), and excluding those evacuated, the case fatality rate was 49% (95% CI 33%-65%). No pregnant women were admitted. At admission 9/44 had stage 1 disease (fever and constitutional symptoms only), 12/44 had stage 2 disease (presence of diarrhoea and/or vomiting) and 23/44 had stage 3 disease (presence of diarrhoea and/or vomiting with organ failure), with case fatality rates of 11% (95% CI 1%-58%), 27% (95% CI 6%-61%), and 70% (95% CI 47%-87%) respectively (p = 0.009). Haemorrhage occurred in 17/41 (41%) patients. The majority (21/40) of patients had hypokalaemia with hyperkalaemia occurring in 12/40 patients. Acute kidney injury (AKI) occurred in 20/40 patients, with 14/20 (70%, 95% CI 46%-88%) dying, compared to 5/20 (25%, 95% CI 9%-49%) dying who did not have AKI (p = 0.01). Ebola virus (EBOV) PCR cycle threshold value at baseline was mean 20.3 (SD 4.3) in fatal cases and 24.8 (SD 5.5) in survivors (p = 0.007). Mean national early warning score (NEWS) at admission was 5.5 (SD 4.4) in fatal cases and 3.0 (SD 1.9) in survivors (p = 0.02). Central venous catheters were placed in 37/41 patients and intravenous fluid administered to 40/41 patients (median duration of 5 days). Faecal management systems were inserted in 21/41 patients, urinary catheters placed in 27/41 and blood component therapy administered to 20/41 patients. CONCLUSIONS: EVD is commonly associated life-threatening electrolyte imbalance and organ dysfunction. We believe that the enhanced levels of protocolized care, scale and range of medical interventions we report, offer a blueprint for the future management of EVD in resource-limited settings.