Intraoperative Prophylaxis with Palonosetron for Postoperative Nausea and/or Vomiting in Adults Undergoing Cardiothoracic Surgery Under General Anesthesia: A Single-Center Retrospective Study.

OBJECTIVE: This study assessed the efficacy of palonosetron, alone or with dexamethasone, in reducing postoperative nausea and/or vomiting (PONV) and its impact on hospitalization duration in patients who undergo adult cardiothoracic surgery (CTS) under general anesthesia. DESIGN: This retrospective analysis involved 540 adult patients who underwent CTS from a single-center cohort, spanning surgeries between September 2021 and March 2023. Sensitivity, logistic, and Cox regression analyses evaluated antiemetic effects, PONV risk factors, and outcomes. SETTING: At the Virginia Mason Medical Center (VMMC), Seattle, WA. PARTICIPANTS: Adults undergoing cardiothoracic surgery at VMMC during the specified period. INTERVENTIONS: Patients were categorized into the following 4 groups based on antiemetic treatment: dexamethasone, palonosetron, dexamethasone with palonosetron, and no antiemetic. MEASUREMENTS AND MAIN RESULTS: Primary outcomes encompassed PONV incidence within 96 hours postoperatively. Secondary outcomes included intensive care unit stay duration and postoperative opioid use. Palonosetron recipients showed a significantly lower PONV rate of 42% (v controls at 63%). The dexamethasone and palonosetron combined group also demonstrated a lower rate of 40%. Sensitivity analysis revealed a notably lower 0- to 12-hour PONV rate for palonosetron recipients (9% v control at 28%). Logistic regression found decreased PONV risk (palonosetron odds ratio [OR]: 0.24; dexamethasone and palonosetron OR: 0.26). Cox regression identified varying PONV hazard ratios related to female sex, PONV history, and lower body mass index. CONCLUSIONS: This single-center retrospective study underscored palonosetron's efficacy, alone or combined with dexamethasone, in managing PONV among adult patients who undergo CTS. These findings contribute to evolving antiemetic strategies in cardiothoracic surgery, potentially impacting patient outcomes and satisfaction positively.

Continuous Pectoral Fascia Blocks for Postoperative Analgesia After Median Sternotomy: A Case Report.

We report a novel case of a patient who presented for aortic valve replacement via median sternotomy. Bilateral continuous pectoral fascia blocks were placed to provide postoperative analgesia. Both numerical rating scale pain scores and opioid consumption after surgery were suggestive of analgesic benefit.

Bilateral paramedian thalamic and mesencephalic infarcts in a newborn due to occlusion of the artery of Percheron.

Bilateral paramedian thalamic and mesencephalic infarcts are infrequently reported in adults, and to our knowledge, has never been reported in a child. The presumed etiology is an occlusion of the artery of Percheron, an uncommon vascular variation, in which a single common trunk from one of the P1 segments of the posterior cerebral artery provides bilateral irrigation to the paramedian thalami and midbrain. Bilateral paramedian thalamic and mesencephalic infarcts in adults are associated with symptoms of decreased arousal, vertical gaze paresis, mood changes, and memory difficulties. Although some improvement of these symptoms does occur, complete recovery is rare. We present here a full-term male neonate, whose right-hand sided clonic seizures on day-of-life 2 prompted neuroimaging, which revealed bilateral paramedian thalamic and mesencephalic infarcts, suggestive of an occlusion of the artery of Percheron.