Detalhe da pesquisa
1.
Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies.
Nucleic Acids Res
; 51(11): 5325-5340, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216594
2.
Visualizing a protonated RNA state that modulates microRNA-21 maturation.
Nat Chem Biol
; 17(1): 80-88, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33106660
3.
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).
J Am Chem Soc
; 144(46): 21096-21102, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342850
4.
NMR characterization of RNA small molecule interactions.
Methods
; 167: 66-77, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31128236
5.
Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule.
ACS Chem Biol
; 18(11): 2336-2342, 2023 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870980
6.
Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy.
ACS Cent Sci
; 9(7): 1342-1353, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37521782
7.
Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity.
Curr Opin Chem Biol
; 62: 119-129, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34118759
8.
A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.
ACS Chem Neurosci
; 12(21): 4076-4089, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34677935
9.
Probing excited conformational states of nucleic acids by nitrogen CEST NMR spectroscopy.
J Magn Reson
; 310: 106642, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31785475
10.
Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.
ACS Chem Biol
; 15(12): 3112-3123, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33196168