RESUMO
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Different treatment options are now possible both for surgical candidates and for those NSCLC patients deemed not suitable for surgery. Despite the treatments available, only a limited number of less advanced stages are potentially curable, with many patients suffering local recurrence or distant metastases. FDG-PET/CT is commonly used in many centers for post-treatment evaluation, follow-up, or surveillance; Nonetheless, there is no clear consensus regarding the indications in these cases. Based upon the results of a literature review and local expertise from a large lung cancer unit, we built clinical evidence-based recommendations for the use of FDG-PET/CT in response assessment. We found that in general this is not recommended earlier than 3 months from treatment; however, as described in detail the correct timing will also depend upon the type of treatment used. We also present a structured approach to assessing treatment changes when reporting FDG-PET/CT, using visual or quantitative approaches.
Assuntos
Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/terapia , Neoplasias Pulmonares/patologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem , Carcinoma Pulmonar de Células não Pequenas/terapia , Carcinoma Pulmonar de Células não Pequenas/patologia , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons/métodosRESUMO
We present the first known application of preoperative percutaneous management of cerebral malperfusion in a patient with acute near-total occlusion of the right common carotid artery with left hemiplegia complicating an acute Stanford type A aortic dissection.
Assuntos
Aneurisma da Aorta Torácica/cirurgia , Dissecção Aórtica/cirurgia , Transtornos Cerebrovasculares/terapia , Doença Aguda , Idoso , Dissecção Aórtica/complicações , Aneurisma da Aorta Torácica/complicações , Artéria Carótida Primitiva , Estenose das Carótidas/complicações , Procedimentos Endovasculares , Humanos , Masculino , StentsAssuntos
Doença de Alzheimer , Disfunção Cognitiva , Estados Unidos , Humanos , Doença de Alzheimer/diagnóstico por imagem , Doença de Alzheimer/tratamento farmacológico , United States Food and Drug Administration , Peptídeos beta-Amiloides/metabolismo , Amiloide/metabolismo , Tomografia por Emissão de Pósitrons/métodos , Encéfalo/metabolismo , Proteínas tau/metabolismoRESUMO
Recent work has shown that attentional deficits following stroke can be modulated by motivational stimulation, particularly anticipated monetary reward. Here we examined the effects of anticipated reward on the pathological attentional blink (AB), an index of temporal selective attention, which is prolonged in patients with right hemisphere damage and a history of left neglect. We specifically compared the effects of reward versus feedback-without-reward on the AB in 17 patients. We found that the patients all manifested impaired performance compared to healthy controls and that reward modulated the pathological blink in the patient group, but only in the second experimental session. When the performance of patients whose neglect had recovered was compared with that of patients who had ongoing or persistent neglect, reward appeared to only influence the AB in the former. These results have implications for our understanding of motivation-attention interactions following right hemisphere stroke, and how they may impact upon recovery from spatial neglect.