Simultaneous electrochemical determination of nitrofurantoin and nifedipine with assistance of needle-shaped perovskite structure: barium stannate fabricated glassy carbon electrode.

A needle-shaped perovskite, barium stannate (BaSnO3), was synthesized via a co-precipitation technique for the simultaneous electrochemical determination of antibiotic drug nitrofurantoin (NFTO) and pericardial drug nifedipine (NFP). The spectroscopic and microscopic result confirms that as-prepared BaSnO3 particles formed with desired crystalline nature, functional group, pore size, pore diameter, and fine needle-like morphology. The simultaneous electrochemical detection of the two pharmaceutical compounds was examined via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) technique using BaSnO3-modified glassy carbon electrode (BaSnO3/GCE) at a potential range from +0.4 to - 1.2 V. The discrete and simultaneous detection of NFTO and NFP at the BaSnO3 sensor exhibits higher catalytic activity in terms of cathodic current and cathodic potential compared to bare GCE. DPV results of the BaSnO3 sensor provide improved linear ranges and limits of detection for NFTO (0.01-42.65 µM; 42.65-557.65 µM, 0.062 µM, respectively) and NFP (0.01-697.65 µM, 0.0168 µM, respectively). Besides, the BaSnO3-fabricated sensor exhibits good sensitivity, reproducibility, and repeatability. The modified electrode shows excellent recoveries of NFTO (97.0-100.7%) and NFP (98.7-101.3%) in plasma, urine, and milk samples with an acceptable relative standard deviation (RSD) of 1.6-4.8%. Graphical abstract Needle-shaped BaSnO3 perovskite material for simultaneous electrochemical sensing of pharmaceutical drugs.

Temperature abetted synthesis of novel magnesium stannate nanoparticles assisted for nanomolar level detection of hazardous flavonoid in biological samples.

Fabrication of temperature-influenced nanoparticles over the superficial region of glassy carbon electrode (GCE) stimulates the electrocatalytic activity owing to their morphology, defective sites, and higher active surface area, etc. In this regard, we have fabricated annealed magnesium stannate nanoparticles (Mg2SnO4 NPs) on GCE for nanomolar level detection of hazardous flavoring and pharmaceutical compound Rutin (RT). To analyze the impact of temperature, we have compared annealed Mg2SnO4 NPs with unannealed magnesium stannate hydrate (MgSnO3·3H2O) particles. The physicochemical properties of synthesized materials were characterized with different microscopic and spectroscopic techniques. From these studies, annealed Mg2SnO4 NPs formed purely without any flith and existence of water molecules as compared to unannealed MgSnO3·3H2O. Moreover as fabricated, Mg2SnO4 NPs/GCE outcomes with higher redox behavior compared to other electrodes in presence of RT at optimized working buffer (pH = 7.0). Interestingly, the electrode successfully established a dual wider linear response (0.062-34.8 & 34.8-346.8 µM) with a nanomolar detection limit (1 nM) and higher sensitivity. The practicability analysis of the proposed sensor also affords excellent selectivity, reproducibility, repeatability, reversibility, and storage stability. Furthermore, the real sample analysis was carried out in blood and orange samples fallout with better recovery results.