Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms.

Non-alcoholic fatty liver disease (NAFLD), with a global prevalence of 25%, continues to escalate, creating noteworthy concerns towards the global health burden. NAFLD causes triglycerides and free fatty acids to build up in the liver. The excessive fat build-up causes inflammation and damages the healthy hepatocytes, leading to non-alcoholic steatohepatitis (NASH). Dietary habits, obesity, insulin resistance, type 2 diabetes, and dyslipidemia influence NAFLD progression. The disease burden is complicated due to the paucity of therapeutic interventions. Obeticholic acid is the only approved therapeutic agent for NAFLD. With more scientific enterprise being directed towards the understanding of the underlying mechanisms of NAFLD, novel targets like lipid synthase, farnesoid X receptor signalling, peroxisome proliferator-activated receptors associated with inflammatory signalling, and hepatocellular injury have played a crucial role in the progression of NAFLD to NASH. Phytocompounds have shown promising results in modulating hepatic lipid metabolism and de novo lipogenesis, suggesting their possible role in managing NAFLD. This review discusses the ameliorative role of different classes of phytochemicals with molecular mechanisms in different cell lines and established animal models. These compounds may lead to the development of novel therapeutic strategies for NAFLD progression to NASH. This review also deliberates on phytomolecules undergoing clinical trials for effective management of NAFLD.

Increased habitat connectivity induces diversity via noise-induced symmetry breaking.

Stochasticity or noise is omnipresent in ecosystems that mediates community dynamics. The beneficial role of stochasticity in enhancing species coexistence and, hence, in promoting biodiversity is well recognized. However, incorporating stochastic birth and death processes in excitable slow-fast ecological systems to study its response to biodiversity is largely unexplored. Considering an ecological network of excitable consumer-resource systems, we study the interplay of network structure and noise on species' collective dynamics. We find that noise drives the system out of the excitable regime, and high habitat patch connectance in the ordered as well as random networks promotes species' diversity by inducing new steady states via noise-induced symmetry breaking.

Effect of fractional derivatives on amplitude chimeras and symmetry-breaking death states in networks of limit-cycle oscillators.

We study networks of coupled oscillators whose local dynamics are governed by the fractional-order versions of the paradigmatic van der Pol and Rayleigh oscillators. We show that the networks exhibit diverse amplitude chimeras and oscillation death patterns. The occurrence of amplitude chimeras in a network of van der Pol oscillators is observed for the first time. A form of amplitude chimera, namely, "damped amplitude chimera" is observed and characterized, where the size of the incoherent region(s) increases continuously in the course of time, and the oscillations of drifting units are damped continuously until they are quenched to steady state. It is found that as the order of the fractional derivative decreases, the lifetime of classical amplitude chimeras increases, and there is a critical point at which there is a transition to damped amplitude chimeras. Overall, a decrease in the order of fractional derivatives reduces the propensity to synchronization and promotes oscillation death phenomena including solitary oscillation death and chimera death patterns that were unobserved in networks of integer-order oscillators. This effect of the fractional derivatives is verified by the stability analysis based on the properties of the master stability function of some collective dynamical states calculated from the block-diagonalized variational equations of the coupled systems. The present study generalizes the results of our recently studied network of fractional-order Stuart-Landau oscillators.

Space-dependent intermittent feedback can control birhythmicity.

Birhythmicity is evident in many nonlinear systems, which include physical and biological systems. In some living systems, birhythmicity is necessary for response to the varying environment while unnecessary in some physical systems as it limits their efficiency. Therefore, its control is an important area of research. This paper proposes a space-dependent intermittent control scheme capable of controlling birhythmicity in various dynamical systems. We apply the proposed control scheme in five nonlinear systems from diverse branches of natural science and demonstrate that the scheme is efficient enough to control the birhythmic oscillations in all the systems. We derive the analytical condition for controlling birhythmicity by applying harmonic decomposition and energy balance methods in a birhythmic van der Pol oscillator. Further, the efficacy of the control scheme is investigated through numerical and bifurcation analyses in a wide parameter space. Since the proposed control scheme is general and efficient, it may be employed to control birhythmicity in several dynamical systems.

Impulsive feedback control of birhythmicity: Theory and experiment.

We study the dynamic control of birhythmicity under an impulsive feedback control scheme where the feedback is made ON for a certain rather small period of time and for the rest of the time, it is kept OFF. We show that, depending on the height and width of the feedback pulse, the system can be brought to any of the desired limit cycles of the original birhythmic oscillation. We derive a rigorous analytical condition of controlling birhythmicity using the harmonic decomposition and energy balance methods. The efficacy of the control scheme is investigated through numerical analysis in the parameter space. We demonstrate the robustness of the control scheme in a birhythmic electronic circuit where the presence of noise and parameter fluctuations are inevitable. Finally, we demonstrate the applicability of the control scheme in controlling birhythmicity in diverse engineering and biochemical systems and processes, such as an energy harvesting system, a glycolysis process, and a p53-mdm2 network.

Revival of oscillation and symmetry breaking in coupled quantum oscillators.

Restoration of oscillations from an oscillation suppressed state in coupled oscillators is an important topic of research and has been studied widely in recent years. However, the same in the quantum regime has not been explored yet. Recent works established that under certain coupling conditions, coupled quantum oscillators are susceptible to suppression of oscillations, such as amplitude death and oscillation death. In this paper, for the first time, we demonstrate that quantum oscillation suppression states can be revoked and rhythmogenesis can be established in coupled quantum oscillators by controlling a feedback parameter in the coupling path. However, in sharp contrast to the classical system, we show that in the deep quantum regime, the feedback parameter fails to revive oscillations, and rather results in a transition from a quantum amplitude death state to the recently discovered quantum oscillation death state. We use the formalism of an open quantum system and a phase space representation of quantum mechanics to establish our results. Therefore, our study establishes that the revival scheme proposed for classical systems does not always result in restoration of oscillations in quantum systems, but in the deep quantum regime, it may give counterintuitive behaviors that are of a pure quantum mechanical origin.

Effects of propagation delay in coupled oscillators under direct-indirect coupling: Theory and experiment.

Propagation delay arises in a coupling channel due to the finite propagation speed of signals and the dispersive nature of the channel. In this paper, we study the effects of propagation delay that appears in the indirect coupling path of direct (diffusive)-indirect (environmental) coupled oscillators. In sharp contrast to the direct coupled oscillators where propagation delay induces amplitude death, we show that in the case of direct-indirect coupling, even a small propagation delay is conducive to an oscillatory behavior. It is well known that simultaneous application of direct and indirect coupling is the general mechanism for amplitude death. However, here we show that the presence of propagation delay hinders the death state and helps the revival of oscillation. We demonstrate our results by considering chaotic time-delayed oscillators and FitzHugh-Nagumo oscillators. We use linear stability analysis to derive the explicit conditions for the onset of oscillation from the death state. We also verify the robustness of our results in an electronic hardware level experiment. Our study reveals that the effect of time delay on the dynamics of coupled oscillators is coupling function dependent and, therefore, highly non-trivial.

Oscillating synchronization in delayed oscillators with time-varying time delay coupling: Experimental observation.

The time-varying time-delayed (TVTD) systems attract the attention of research communities due to their rich complex dynamics and wide application potentiality. Particularly, coupled TVTD systems show several intriguing behaviors that cannot be observed in systems with a constant delay or no delay. In this context, a new synchronization scenario, namely, oscillating synchronization, was reported by Senthilkumar and Lakshmanan [Chaos 17, 013112 (2007)], which is exclusive to the time-varying time delay systems only. However, like most of the dynamical behavior of TVTD systems, its existence has not been established in an experiment. In this paper, we report the first experimental observation of oscillating synchronization in coupled nonlinear time-delayed oscillators induced by a time-varying time delay in the coupling path. We implement a simple yet effective electronic circuit to realize the time-varying time delay in an experiment. We show that depending upon the instantaneous variation of the time delay, the system shows a synchronization scenario oscillating among lag, complete, and anticipatory synchronization. This study may open up the feasibility of applying oscillating synchronization in engineering systems.

Chimeras in digital phase-locked loops.

Digital phase-locked loops (DPLLs) are nonlinear feedback-controlled systems that are widely used in electronic communication and signal processing applications. In most of the applications, they work in coupled mode; however, a vast amount of the studies on DPLLs concentrate on the dynamics of a single isolated unit. In this paper, we consider both one- and two-dimensional networks of DPLLs connected through a practically realistic nonlocal coupling and explore their collective dynamics. For the one-dimensional network, we analytically derive the parametric zone of a stable phase-locked state in which DPLLs essentially work in their normal mode of operation. We demonstrate that apart from the stable phase-locked state, a variety of spatiotemporal structures including chimeras arise in a broad parameter zone. For the two-dimensional network under nonlocal coupling, we identify several variants of chimera patterns, such as strip and spot chimeras. We identify and characterize the chimera patterns through suitable measures like local curvature and correlation function. Our study reveals the existence of chimeras in a widely used engineering system; therefore, we believe that these chimera patterns can be observed in experiments as well.

Long-range dispersal promotes species persistence in climate extremes.

Anthropogenic global warming in this century can act as a leading factor for large scale species extinctions in the near future. Species, in order to survive, need to develop dispersal strategies depending upon their environmental niche. Based on empirical evidence only a few previous studies have addressed how dispersal can evolve with changing temperature. However, for the analytical tractability, there is a need to develop an explicit model to ask how the temperature-dependent dispersal alters ecological dynamics. We investigate the persistence of species in a spatial ecological model, where dispersal is considered as a function of temperature. Spatial persistence is of major concern and dispersal is reasonably an important factor for extinction risk in the context of promoting synchrony. Our study yields how the temperature influences species decision of dispersal, resulting in either short-range or long-range dispersal. We examine synchronous or asynchronous behavior of species under their thermal dependence of dispersal. Moreover, we also analyze the transients to study the collective behavior of species away from their final or asymptotic dynamics. One of the key findings is at the most unfavorable environmental conditions long-range dispersal works out as the driving force for the persistence of species.

Networks of coupled oscillators: From phase to amplitude chimeras.

We show that amplitude-mediated phase chimeras and amplitude chimeras can occur in the same network of nonlocally coupled identical oscillators. These are two different partial synchronization patterns, where spatially coherent domains coexist with incoherent domains and coherence/incoherence referring to both amplitude and phase or only the amplitude of the oscillators, respectively. By changing the coupling strength, the two types of chimera patterns can be induced. We find numerically that the amplitude chimeras are not short-living transients but can have a long lifetime. Also, we observe variants of the amplitude chimeras with quasiperiodic temporal oscillations. We provide a qualitative explanation of the observed phenomena in the light of symmetry breaking bifurcation scenarios. We believe that this study will shed light on the connection between two disparate chimera states having different symmetry-breaking properties.

Control of birhythmicity: A self-feedback approach.

Birhythmicity occurs in many natural and artificial systems. In this paper, we propose a self-feedback scheme to control birhythmicity. To establish the efficacy and generality of the proposed control scheme, we apply it on three birhythmic oscillators from diverse fields of natural science, namely, an energy harvesting system, the p53-Mdm2 network for protein genesis (the OAK model), and a glycolysis model (modified Decroly-Goldbeter model). Using the harmonic decomposition technique and energy balance method, we derive the analytical conditions for the control of birhythmicity. A detailed numerical bifurcation analysis in the parameter space establishes that the control scheme is capable of eliminating birhythmicity and it can also induce transitions between different forms of bistability. As the proposed control scheme is quite general, it can be applied for control of several real systems, particularly in biochemical and engineering systems.

Control of bifurcation-delay of slow passage effect by delayed self-feedback.

The slow passage effect in a dynamical system generally induces a delay in bifurcation that imposes an uncertainty in the prediction of the dynamical behaviors around the bifurcation point. In this paper, we investigate the influence of linear time-delayed self-feedback on the slow passage through the delayed Hopf and pitchfork bifurcations in a parametrically driven nonlinear oscillator. We perform linear stability analysis to derive the Hopf bifurcation point and its stability as a function of self-feedback time delay. Interestingly, the bifurcation-delay associated with Hopf bifurcation behaves differently in two different edges. In the leading edge of the modulating signal, it decreases with increasing self-feedback delay, whereas in the trailing edge, it behaves in an opposite manner. We also show that the linear time-delayed self-feedback can reduce bifurcation-delay in pitchfork bifurcation. These results are illustrated numerically and corroborated experimentally. We also propose a mechanistic explanation of the observed behaviors. In addition, we show that our observations are robust in the presence of noise. We believe that this study of interplay of two time delays of different origins will shed light on the control of bifurcation-delay and improve our knowledge of time-delayed systems.

Generation and cessation of oscillations: Interplay of excitability and dispersal in a class of ecosystems.

We investigate the complex spatiotemporal dynamics of an ecological network with species dispersal mediated via a mean-field coupling. The local dynamics of the network are governed by the Truscott-Brindley model, which is an important ecological model showing excitability. Our results focus on the interplay of excitability and dispersal by always considering that the individual nodes are in their (excitable) steady states. In contrast to the previous studies, we not only observe the dispersal induced generation of oscillation but also report two distinct mechanisms of cessation of oscillations, namely, amplitude and oscillation death. We show that the dispersal between the nodes influences the intrinsic dynamics of the system resulting in multiple oscillatory dynamics such as period-1 and period-2 limit cycles. We also show the existence of multi-cluster states, which has much relevance and importance in ecology.

Dispersal-induced synchrony, temporal stability, and clustering in a mean-field coupled Rosenzweig-MacArthur model.

In spatial ecology, dispersal among a set of spatially separated habitats, named as metapopulation, preserves the diversity and persistence by interconnecting the local populations. Understanding the effects of several variants of dispersion in metapopulation dynamics and to identify the factors which promote population synchrony and population stability are important in ecology. In this paper, we consider the mean-field dispersion among the habitats in a network and study the collective dynamics of the spatially extended system. Using the Rosenzweig-MacArthur model for individual patches, we show that the population synchrony and temporal stability, which are believed to be of conflicting outcomes of dispersion, can be simultaneously achieved by oscillation quenching mechanisms. Particularly, we explore the more natural coupling configuration where the rates of dispersal of different habitats are disparate. We show that asymmetry in dispersal rate plays a crucial role in determining inhomogeneity in an otherwise homogeneous metapopulation. We further identify an unusual emergent state in the network, namely, a multi-branch clustered inhomogeneous steady state, which arises due to the intrinsic parameter mismatch among the patches. We believe that the present study will shed light on the cooperative behavior of spatially structured ecosystems.

Spatiotemporal dynamics of a digital phase-locked loop based coupled map lattice system.

We explore the spatiotemporal dynamics of a coupled map lattice (CML) system, which is realized with a one dimensional array of locally coupled digital phase-locked loops (DPLLs). DPLL is a nonlinear feedback-controlled system widely used as an important building block of electronic communication systems. We derive the phase-error equation of the spatially extended system of coupled DPLLs, which resembles a form of the equation of a CML system. We carry out stability analysis for the synchronized homogeneous solutions using the circulant matrix formalism. It is shown through extensive numerical simulations that with the variation of nonlinearity parameter and coupling strength the system shows transitions among several generic features of spatiotemporal dynamics, viz., synchronized fixed point solution, frozen random pattern, pattern selection, spatiotemporal intermittency, and fully developed spatiotemporal chaos. We quantify the spatiotemporal dynamics using quantitative measures like average quadratic deviation and spatial correlation function. We emphasize that instead of using an idealized model of CML, which is usually employed to observe the spatiotemporal behaviors, we consider a real world physical system and establish the existence of spatiotemporal chaos and other patterns in this system. We also discuss the importance of the present study in engineering application like removal of clock-skew in parallel processors.

Amplitude death and synchronized states in nonlinear time-delay systems coupled through mean-field diffusion.

We explore and experimentally demonstrate the phenomena of amplitude death (AD) and the corresponding transitions through synchronized states that lead to AD in coupled intrinsic time-delayed hyperchaotic oscillators interacting through mean-field diffusion. We identify a novel synchronization transition scenario leading to AD, namely transitions among AD, generalized anticipatory synchronization (GAS), complete synchronization (CS), and generalized lag synchronization (GLS). This transition is mediated by variation of the difference of intrinsic time-delays associated with the individual systems and has no analogue in non-delayed systems or coupled oscillators with coupling time-delay. We further show that, for equal intrinsic time-delays, increasing coupling strength results in a transition from the unsynchronized state to AD state via in-phase (complete) synchronized states. Using Krasovskii-Lyapunov theory, we derive the stability conditions that predict the parametric region of occurrence of GAS, GLS, and CS; also, using a linear stability analysis, we derive the condition of occurrence of AD. We use the error function of proper synchronization manifold and a modified form of the similarity function to provide the quantitative support to GLS and GAS. We demonstrate all the scenarios in an electronic circuit experiment; the experimental time-series, phase-plane plots, and generalized autocorrelation function computed from the experimental time series data are used to confirm the occurrence of all the phenomena in the coupled oscillators.

Aging transition in coupled quantum oscillators.

Aging transition is an emergent behavior observed in networks consisting of active (self-oscillatory) and inactive (non-self-oscillatory) nodes, where the network transits from a global oscillatory state to an oscillation collapsed state when the fraction of inactive oscillators surpasses a critical value. However, the aging transition in quantum domain has not been studied yet. In this paper we investigate the quantum manifestation of aging transition in a network of active-inactive quantum oscillators. We show that, unlike classical case, the quantum aging is not characterized by a complete collapse of oscillation but by sufficient reduction in the mean boson number. We identify a critical "knee" value in the fraction of inactive oscillators around which quantum aging occurs in two different ways. Further, in stark contrast to the classical case, quantum aging transition depends upon the nonlinear damping parameter. We also explain the underlying processes leading to quantum aging that have no counterpart in the classical domain.

Stability of ecosystems under oscillatory driving with frequency modulation.

Consumer-resource cycles are widespread in ecosystems, and seasonal forcing is known to influence them profoundly. Typically, seasonal forcing perturbs an ecosystem with time-varying frequency; however, previous studies have explored the dynamics of such systems under oscillatory forcing with constant frequency. Studies of the effect of time-varying frequency on ecosystem stability are lacking. Here we investigate isolated and network models of a cyclic consumer-resource ecosystem with oscillatory driving subjected to frequency modulation. We show that frequency modulation can induce stability in the system in the form of stable synchronized solutions, depending on intrinsic model parameters and extrinsic modulation strength. The stability of synchronous solutions is determined by calculating the maximal Lyapunov exponent, which determines that the fraction of stable synchronous solution increases with an increase in the modulation strength. We also uncover intermittent synchronization when synchronous dynamics are intermingled with episodes of asynchronous dynamics. Using the phase-reduction method for the network model, we reduce the system into a phase equation that clearly distinguishes synchronous, intermittently synchronous, and asynchronous solutions. While investigating the role of network topology, we find that variation in rewiring probability has a negligible effect on the stability of synchronous solutions. This study deepens our understanding of ecosystems under seasonal perturbations.

Chimera patterns with spatial random swings between periodic attractors in a network of FitzHugh-Nagumo oscillators.

For the study of symmetry-breaking phenomena in neuronal networks, simplified versions of the FitzHugh-Nagumo model are widely used. In this paper, these phenomena are investigated in a network of FitzHugh-Nagumo oscillators taken in the form of the original model and it is found that it exhibits diverse partial synchronization patterns that are unobserved in the networks with simplified models. Apart from the classical chimera, we report a new type of chimera pattern whose incoherent clusters are characterized by spatial random swings among a few fixed periodic attractors. Another peculiar hybrid state is found that combines the features of this chimera state and a solitary state such that the main coherent cluster is interspersed with some nodes with identical solitary dynamics. In addition, oscillation death including chimera death emerges in this network. A reduced model of the network is derived to study oscillation death, which helps explaining the transition from spatial chaos to oscillation death via the chimera state with a solitary state. This study deepens our understanding of chimera patterns in neuronal networks.