Vehicle Detection and Attribution from a Multi-Sensor Dataset Using a Rule-Based Approach Combined with Data Fusion.

Vehicle detection using data fusion techniques from overhead platforms (RGB/MSI imagery and LiDAR point clouds) with vector and shape data can be a powerful tool in a variety of fields, including, but not limited to, national security, disaster relief efforts, and traffic monitoring. Knowing the location and number of vehicles in a given area can provide insight into the surrounding activities and patterns of life, as well as support decision-making processes. While researchers have developed many approaches to tackling this problem, few have exploited the multi-data approach with a classical technique. In this paper, a primarily LiDAR-based method supported by RGB/MSI imagery and road network shapefiles has been developed to detect stationary vehicles. The addition of imagery and road networks, when available, offers an improved classification of points from LiDAR data and helps to reduce false positives. Furthermore, detected vehicles can be assigned various 3D, relational, and spectral attributes, as well as height profiles. This method was evaluated on the Houston, TX dataset provided by the IEEE 2018 GRSS Data Fusion Contest, which includes 1476 ground truth vehicles from LiDAR data. On this dataset, the algorithm achieved a 92% precision and 92% recall. It was also evaluated on the Vaihingen, Germany dataset provided by ISPRS, as well as data simulated using an image generation model called DIRSIG. Some known limitations of the algorithm include false positives caused by low vegetation and the inability to detect vehicles (1) in extremely close proximity with high precision and (2) from low-density point clouds.

Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation.

The purpose of this study was to determine whether a dietary supplement consisting of L-selenomethionine, vitamin C, vitamin E succinate, alpha-lipoic acid and N-acetyl cysteine could improve the survival of mice after total-body irradiation. Antioxidants significantly increased the 30-day survival of mice after exposure to a potentially lethal dose of X rays when given prior to or after animal irradiation. Pretreatment of animals with antioxidants resulted in significantly higher total white blood cell and neutrophil counts in peripheral blood at 4 and 24 h after 1 Gy and 8 Gy. Antioxidants were effective in preventing peripheral lymphopenia only after low-dose irradiation. Antioxidant supplementation was also associated with increased bone marrow cell counts after irradiation. Supplementation with antioxidants was associated with increased Bcl2 and decreased Bax, caspase 9 and TGF-beta1 mRNA expression in the bone marrow after irradiation. Maintenance of the antioxidant diet was associated with improved recovery of the bone marrow after sublethal or potentially lethal irradiation. Taken together, oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival, and modulation of apoptosis is implicated as a mechanism for the radioprotection of the hematopoietic system by antioxidants.

A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice.

The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central nervous systems. Yet with advancing age, androgens can drive the onset of prostate cancer, the second leading cause of cancer death in males within the United States. Androgen deprivation therapy (ADT) by pharmacologic and/or surgical castration induces apoptosis of prostate cells and subsequent shrinkage of the prostate and prostate tumors. However, ADT is associated with significant musculoskeletal and behavioral adverse effects. The unique pharmacological activity of selective androgen receptor modulator (SARM) MK-4541 recently has been reported as an AR antagonist with 5α-reductase inhibitor function. The molecule inhibits proliferation and induces apoptosis in AR positive, androgen dependent prostate cancer cells. Importantly, MK-4541 inhibited androgen-dependent prostate growth in male rats yet maintained lean body mass and bone formation following ovariectomy in female rats. In the present study, we evaluated the effects of SARM MK-4541 in the androgen-dependent Dunning R3327-G prostate carcinoma xenograft mouse model as well as on skeletal muscle mass and function, and AR-regulated behavior in mice. MK-4541 significantly inhibited the growth of R3327-G prostate tumors, exhibited anti-androgen effects on the seminal vesicles, reduced plasma testosterone concentrations in intact males, and inhibited Ki67 expression. MK-4541 treated xenografts appeared similar to xenografts in castrated mice. Importantly, we demonstrate that MK-4541 exhibited anabolic activity in androgen deficient conditions, increasing lean body mass and muscle function in adult castrated mice. Moreover, MK-4541 treatment restored general activity levels in castrated mice. Thus, MK-4541 exhibits an optimum profile as an adjuvant therapy to ADT which may provide potent anti-androgenic activity at the prostate yet protective activity on skeletal muscle and behavior in patients.