Detalhe da pesquisa
1.
Selective small-molecule inhibition of an RNA structural element.
Nature
; 526(7575): 672-7, 2015 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416753
2.
Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals.
J Pharmacol Exp Ther
; 360(3): 466-475, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28035006
3.
Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.
RNA Biol
; 13(10): 946-954, 2016 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27485612
4.
A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta.
Proteins
; 83(2): 309-17, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25388768
5.
Structures of apo- and ssDNA-bound YdbC from Lactococcus lactis uncover the function of protein domain family DUF2128 and expand the single-stranded DNA-binding domain proteome.
Nucleic Acids Res
; 41(4): 2756-68, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23303792
6.
Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling.
Methods Enzymol
; 667: 685-727, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35525559
7.
Regulation of response regulator autophosphorylation through interdomain contacts.
J Biol Chem
; 285(42): 32325-35, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20702407
8.
Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding.
Structure
; 16(5): 727-35, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18462677
9.
Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA.
Nucleic Acids Res
; 35(10): 3272-86, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17452355
10.
Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.
Biochimie
; 90(8): 1233-49, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18439430
11.
Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.
J Mol Biol
; 369(1): 142-56, 2007 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17418235
12.
Universally applicable methods for monitoring response regulator aspartate phosphorylation both in vitro and in vivo using Phos-tag-based reagents.
Anal Biochem
; 376(1): 73-82, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18328252
13.
G-quadruplexes induce apoptosis in tumor cells.
Cancer Res
; 66(24): 11808-16, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17178877
14.
Validation and Development of an Escherichia coli Riboflavin Pathway Phenotypic Screen Hit as a Small-Molecule Ligand of the Flavin Mononucleotide Riboswitch.
Methods Mol Biol
; 1787: 19-40, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736707
15.
Use of 2-aminopurine as a fluorescent tool for characterizing antibiotic recognition of the bacterial rRNA A-site.
Tetrahedron
; 63(17): 3567-6574, 2007 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18431442
16.
Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.
Cell Chem Biol
; 24(5): 576-588.e6, 2017 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434876
17.
Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.
J Mol Biol
; 346(1): 119-34, 2005 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15663932
18.
Drug self-association modulates the cellular bioavailability of DNA minor groove-directed terbenzimidazoles.
J Med Chem
; 49(17): 5245-51, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913713
19.
Moderate to high throughput in vitro binding kinetics for drug discovery.
Front Biosci (Schol Ed)
; 8(2): 278-97, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27100706
20.
Coupling of drug protonation to the specific binding of aminoglycosides to the A site of 16 S rRNA: elucidation of the number of drug amino groups involved and their identities.
J Mol Biol
; 326(5): 1373-87, 2003 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12595251