Detalhe da pesquisa
1.
FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo.
Proc Natl Acad Sci U S A
; 106(5): 1336-41, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164520
2.
Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.
Bioorg Med Chem Lett
; 21(1): 307-10, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21109434
3.
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.
Bioorg Med Chem Lett
; 20(17): 5269-73, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655213
4.
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.
J Med Chem
; 63(4): 1612-1623, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31971798
5.
Allosteric inhibition of protein tyrosine phosphatase 1B.
Nat Struct Mol Biol
; 11(8): 730-7, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15258570
6.
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.
J Med Chem
; 62(14): 6575-6596, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199148
7.
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg Med Chem Lett
; 18(20): 5648-52, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18793847
8.
Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 8): 686-91, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678933
9.
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
J Med Chem
; 45(8): 1697-711, 2002 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11931625
10.
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.
ACS Med Chem Lett
; 3(3): 203-6, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900456
11.
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Bioorg Med Chem Lett
; 12(3): 465-9, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11814821