Detalhe da pesquisa
1.
Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines.
Org Biomol Chem
; 22(4): 767-783, 2024 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167738
2.
Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations.
J Chem Inf Model
; 63(15): 4875-4887, 2023 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37515548
3.
Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy.
Int J Mol Sci
; 24(13)2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37445672
4.
Q-raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation.
J Chem Inf Model
; 62(24): 6309-6315, 2022 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36442071
5.
Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface.
J Neurochem
; 152(1): 136-150, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31264722
6.
Alternate NF-κB-Independent Signaling Reactivation of Latent HIV-1 Provirus.
J Virol
; 93(18)2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243131
7.
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 584-597, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992093
8.
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors.
Int J Mol Sci
; 21(19)2020 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32987835
9.
Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.
Biochem Biophys Res Commun
; 511(3): 579-586, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30824186
10.
Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach.
Int J Mol Sci
; 20(16)2019 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31430864
11.
p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.
Molecules
; 20(9): 15842-61, 2015 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-26334265
12.
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
PLoS Pathog
; 8(6): e1002774, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737073
13.
Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.
J Chem Inf Model
; 54(2): 481-97, 2014 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23952658
14.
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
Bioorg Med Chem
; 22(17): 4658-66, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25127466
15.
Small Molecule Drugs Targeting Viral Polymerases.
Pharmaceuticals (Basel)
; 17(5)2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38794231
16.
Equisetum arvense standardized dried extract hinders age-related osteosarcopenia.
Biomed Pharmacother
; 174: 116517, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574619
17.
Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37513905
18.
Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy.
J Med Chem
; 66(10): 6498-6522, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37134182
19.
Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes.
Eur J Med Chem
; 252: 115283, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36965228
20.
A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.
Virology
; 583: 1-13, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060797