RESUMO
A patient with localized cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis infection was treated with an antigen containing heat-killed L. (L.) amazonensis promastigotes plus BCG. Expression of T-cell differentiation, memory and senescence receptors markers were analyzed on T cell subpopulations, in order to establish the correlation between the percentages of expression of these receptors and his clinical status, at different stages of his follow up. The following case reports on the achievement of a successful clinical outcome with complete resolution after receiving immunotherapy. A thorough clinical and immunological follow up supporting the healing process of this patient's lesion is presented in detail.
Assuntos
Antígenos de Protozoários/uso terapêutico , Vacina BCG/uso terapêutico , Imunoterapia Ativa , Leishmania mexicana/imunologia , Leishmaniose Cutânea/terapia , Doenças Profissionais/terapia , Vacinas Protozoárias/uso terapêutico , Adulto , Antígenos de Protozoários/administração & dosagem , Antígenos de Protozoários/imunologia , Argentina/epidemiologia , Vacina BCG/administração & dosagem , Pesqueiros , Humanos , Imunidade Celular , Memória Imunológica , Injeções Intradérmicas , Úlcera da Perna/etiologia , Úlcera da Perna/parasitologia , Leishmania mexicana/crescimento & desenvolvimento , Leishmaniose Cutânea/epidemiologia , Leishmaniose Cutânea/imunologia , Leishmaniose Cutânea/parasitologia , Masculino , Doenças Profissionais/imunologia , Doenças Profissionais/parasitologia , Vacinas Protozoárias/administração & dosagem , Vacinas Protozoárias/imunologia , Subpopulações de Linfócitos T/imunologia , Vacinas de Produtos InativadosRESUMO
A patient with localized cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis infection was treated with an antigen containing heat-killed L. (L.) amazonensis promastigotes plus BCG. Expression of T-cell differentiation, memory and senescence receptors markers were analyzed on T cell subpopulations, in order to establish the correlation between the percentages of expression of these receptors and his clinical status, at different stages of his follow up. The following case reports on the achievement of a successful clinical outcome with complete resolution after receiving immunotherapy. A thorough clinical and immunological follow up supporting the healing process of this patients lesion is presented in detail.
Un paciente con leishmaniasis cutánea localizada producida por Leishmania (Leishmania) amazonensis fue tratado con un antígeno compuesto por promastigotes de L. (L.) amazonensis muertos por calor combinado con BCG. Se analizó la expresión de distintos receptores de diferenciación, de memoria y de senescencia en las subpoblaciones de células T, con el fin de establecer una relación entre los porcentajes de expresión de dichos receptores y la clínica del paciente en diferentes momentos del seguimiento. Se reporta en este caso un resultado exitoso, con resolución completa de la lesión después de recibir la inmunoterapia, y se presenta en detalle un seguimiento clínico e inmunológico completo durante el proceso de curación.