[Immunoglobulins and complement in pregnant women with EPH gestosis (author's transl)]. / Imunoglobulini i komplement trudnica s EPH gestozom.

In pregnant women with EPH gestosis immunoglobulins in the serum, urine, amnionic fluid, and the umbilical cord serum were determined. The complement value was determined only in mother's serum. The control group consisted of pregnant women without any pathologic changes in the course of pregnancy and with a normal delivery. All children were normal. In the sera of pregnant women with EPH gestosis low IgG and IgM and normal IgA value were recorded. The total hemolytic activity of the complement was within normal, while the C3 component values was somewhat decreased. The finding of decreased IgG values could be explained, partly, by the permeability of the kidney and--the increased concentration of IgG in the urine and partly by the IgG binding into immunocomplexes. The decreased IgM values are assumed to be due to the IgM binding into EPH immunocomplexes. Normal complement values in EPH gestosis do not indicate an active immunologic reaction. Of special interest is the increased IgM level in the serum of the umbilical cord of children from women with EPH gestosis, which remains inexplicable but might suggest an intensified immunological challenge in the fetus.