Detalhe da pesquisa
1.
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Antimicrob Agents Chemother
; 65(10): e0115521, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34310217
2.
Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia.
Chemotherapy
; 63(4): 225-237, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30372692
3.
Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs.
Antiviral Res
; 219: 105718, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37758067
4.
1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity.
J Med Chem
; 66(8): 5802-5819, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040439
5.
A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy.
Mol Vis
; 18: 1907-17, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22876115
6.
Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.
J Am Chem Soc
; 133(7): 2264-74, 2011 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21280608
7.
Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.
Antimicrob Agents Chemother
; 55(1): 35-41, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078944
8.
Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.
Antimicrob Agents Chemother
; 55(11): 5063-72, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896914
9.
Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation.
Mol Vis
; 17: 627-37, 2011 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21386925
10.
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
Bioorg Med Chem
; 19(9): 2950-8, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493074
11.
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.
Bioorg Med Chem
; 19(15): 4616-25, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21719300
12.
Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524).
Microbiol Spectr
; 9(3): e0153721, 2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34817209
13.
Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524).
bioRxiv
; 2021 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34401879
14.
Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs.
bioRxiv
; 2021 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32869033
15.
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
Chemotherapy
; 56(1): 54-9, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20215748
16.
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Antimicrob Agents Chemother
; 53(12): 5284-7, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19704122
17.
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Antimicrob Agents Chemother
; 53(6): 2660-2, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289518
18.
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Antimicrob Agents Chemother
; 53(7): 2865-70, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19398648
19.
Octadecyloxyethyl benzyl tenofovir: A novel tenofovir diester provides sustained intracellular levels of tenofovir diphosphate.
Antiviral Res
; 171: 104614, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31550449
20.
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Antimicrob Agents Chemother
; 52(12): 4326-30, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852272