Pesquisa | BVS IEC

1.

The principles of directed cell migration.

SenGupta, Shuvasree; Parent, Carole A; Bear, James E.

Nat Rev Mol Cell Biol ; 22(8): 529-547, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33990789

2.

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis.

Wu, Congying; Asokan, Sreeja B; Berginski, Matthew E; Haynes, Elizabeth M; Sharpless, Norman E; Griffith, Jack D; Gomez, Shawn M; Bear, James E.

Cell ; 148(5): 973-87, 2012 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-22385962

3.

New insights into the regulation and cellular functions of the ARP2/3 complex.

Rotty, Jeremy D; Wu, Congying; Bear, James E.

Nat Rev Mol Cell Biol ; 14(1): 7-12, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23212475

4.

Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy.

Lee, Rhianna E; Mascenik, Teresa M; Major, Sidra C; Galiger, Jacob R; Bulik-Sullivan, Emily; Siesser, Priscila F; Lewis, Catherine A; Bear, James E; Le Suer, Jake A; Hawkins, Finn J; Pickles, Raymond J; Randell, Scott H.

Am J Physiol Lung Cell Mol Physiol ; 326(3): L226-L238, 2024 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-38150545

5.

G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.

Appalabhotla, Ravikanth; Butler, Mitchell T; Bear, James E; Haugh, Jason M.

Biophys J ; 122(18): 3816-3829, 2023 09 19.

Artigo em Inglês | MEDLINE | ID: mdl-37644720

6.

A kinetic model of phospholipase C-Î³1 linking structure-based insights to dynamics of enzyme autoinhibition and activation.

Nosbisch, Jamie L; Bear, James E; Haugh, Jason M.

J Biol Chem ; 298(5): 101886, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35367415

7.

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation.

Lerner, Andrew M; Hepperla, Austin J; Keele, Gregory R; Meriesh, Hashem A; Yumerefendi, Hayretin; Restrepo, David; Zimmerman, Seth; Bear, James E; Kuhlman, Brian; Davis, Ian J; Strahl, Brian D.

Genome Res ; 30(11): 1605-1617, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-33020206

8.

Follow the monomer.

Bear, James E.

Cell ; 133(5): 765-7, 2008 May 30.

Artigo em Inglês | MEDLINE | ID: mdl-18510919

9.

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.

Cai, Liang; Makhov, Alexander M; Schafer, Dorothy A; Bear, James E.

Cell ; 134(5): 828-42, 2008 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-18775315

10.

Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.

Chandra, Ankit; Butler, Mitchell T; Bear, James E; Haugh, Jason M.

Biophys J ; 121(1): 102-118, 2022 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-34861242

11.

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing.

Nosbisch, Jamie L; Rahman, Anisur; Mohan, Krithika; Elston, Timothy C; Bear, James E; Haugh, Jason M.

PLoS Comput Biol ; 16(4): e1007708, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32255775

12.

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

Freemerman, Alex J; Zhao, Liyang; Pingili, Ajeeth K; Teng, Bin; Cozzo, Alyssa J; Fuller, Ashley M; Johnson, Amy R; Milner, J Justin; Lim, Maili F; Galanko, Joseph A; Beck, Melinda A; Bear, James E; Rotty, Jeremy D; Bezavada, Lavanya; Smallwood, Heather S; Puchowicz, Michelle A; Liu, Juan; Locasale, Jason W; Lee, Douglas P; Bennett, Brian J; Abel, E Dale; Rathmell, Jeff C; Makowski, Liza.

J Immunol ; 202(4): 1265-1286, 2019 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-30659108

13.

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.

Shiow, Lawrence R; Roadcap, David W; Paris, Kenneth; Watson, Susan R; Grigorova, Irina L; Lebet, Tonya; An, Jinping; Xu, Ying; Jenne, Craig N; Föger, Niko; Sorensen, Ricardo U; Goodnow, Christopher C; Bear, James E; Puck, Jennifer M; Cyster, Jason G.

Nat Immunol ; 9(11): 1307-15, 2008 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18836449

14.

Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.

Zimmerman, Seth P; Asokan, Sreeja B; Kuhlman, Brian; Bear, James E.

J Cell Sci ; 130(18): 2971-2983, 2017 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-28754687

15.

Lamellipodia are crucial for haptotactic sensing and response.

King, Samantha J; Asokan, Sreeja B; Haynes, Elizabeth M; Zimmerman, Seth P; Rotty, Jeremy D; Alb, James G; Tagliatela, Alicia; Blake, Devon R; Lebedeva, Irina P; Marston, Daniel; Johnson, Heath E; Parsons, Maddy; Sharpless, Norman E; Kuhlman, Brian; Haugh, Jason M; Bear, James E.

J Cell Sci ; 129(12): 2329-42, 2016 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-27173494

16.

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications.

Yumerefendi, Hayretin; Lerner, Andrew Michael; Zimmerman, Seth Parker; Hahn, Klaus; Bear, James E; Strahl, Brian D; Kuhlman, Brian.

Nat Chem Biol ; 12(6): 399-401, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27089030

17.

Tortuous Microvessels Contribute to Wound Healing via Sprouting Angiogenesis.

Chong, Diana C; Yu, Zhixian; Brighton, Hailey E; Bear, James E; Bautch, Victoria L.

Arterioscler Thromb Vasc Biol ; 37(10): 1903-1912, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28838921

18.

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins.

Guntas, Gurkan; Hallett, Ryan A; Zimmerman, Seth P; Williams, Tishan; Yumerefendi, Hayretin; Bear, James E; Kuhlman, Brian.

Proc Natl Acad Sci U S A ; 112(1): 112-7, 2015 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-25535392

19.

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.

Mohan, Krithika; Nosbisch, Jamie L; Elston, Timothy C; Bear, James E; Haugh, Jason M.

Biophys J ; 113(1): 185-194, 2017 Jul 11.

Artigo em Inglês | MEDLINE | ID: mdl-28700916

20.

Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization.

Zimmerman, Seth P; Hallett, Ryan A; Bourke, Ashley M; Bear, James E; Kennedy, Matthew J; Kuhlman, Brian.

Biochemistry ; 55(37): 5264-71, 2016 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-27529180

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Instituto Evandro Chagas

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