Detalhe da pesquisa
1.
Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions.
PLoS Pathog
; 18(9): e1010832, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121863
2.
Interrogating l-fuconate dehydratase with tartronate and 3-hydroxypyruvate reveals subtle differences within the mandelate racemase-subgroup of the enolase superfamily.
Arch Biochem Biophys
; 754: 109924, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354877
3.
A Phenylboronic Acid-Based Transition State Analogue Yields Nanomolar Inhibition of Mandelate Racemase.
Biochemistry
; 62(12): 1929-1942, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37285384
4.
Altering the binding determinant on the interdigitating loop of mandelate racemase shifts specificity towards that of d-tartrate dehydratase.
Arch Biochem Biophys
; 718: 109119, 2022 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35016855
5.
Slow-Onset, Potent Inhibition of Mandelate Racemase by 2-Formylphenylboronic Acid. An Unexpected Adduct Clasps the Catalytic Machinery.
Biochemistry
; 2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34339165
6.
Heat Shock Proteins in the "Hot" Mitochondrion: Identity and Putative Roles.
Bioessays
; 41(9): e1900055, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31379014
7.
Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center.
Biochemistry
; 59(33): 3026-3037, 2020 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786399
8.
Through the Looking Glass: Chiral Recognition of Substrates and Products at the Active Sites of Racemases and Epimerases.
Chemistry
; 26(46): 10367-10390, 2020 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32166792
9.
Altering the Y137-K164-K166 triad of mandelate racemase and its effect on the observed pKa of the Brønsted base catalysts.
Arch Biochem Biophys
; 666: 116-126, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935886
10.
The role of Brønsted base basicity in estimating carbon acidity at enzyme active sites: a caveat.
Org Biomol Chem
; 17(30): 7161-7165, 2019 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31317156
11.
Substrate-product analogue inhibitors of isoleucine 2-epimerase from Lactobacillus buchneri by rational design.
Org Biomol Chem
; 17(37): 8618-8627, 2019 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31528932
12.
A continuous assay for l-talarate/galactarate dehydratase using circular dichroism.
Anal Biochem
; 544: 80-86, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29248502
13.
Potent dialkyl substrate-product analogue inhibitors and inactivators of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis by rational design.
Bioorg Chem
; 77: 640-650, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29502025
14.
The interdigitating loop of the enolase superfamily as a specificity binding determinant or 'flying buttress'.
Biochim Biophys Acta Proteins Proteom
; 1865(5): 619-630, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28179138
15.
Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5'-Triphosphate.
Chembiochem
; 17(23): 2240-2249, 2016 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27643605
16.
An additional role for the Brønsted acid-base catalysts of mandelate racemase in transition state stabilization.
Biochemistry
; 54(44): 6743-52, 2015 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26480244
17.
Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies.
Biochemistry
; 54(17): 2747-57, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25844917
18.
Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode.
Biochemistry
; 53(7): 1169-78, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24472022
19.
Inhibition of glutamate racemase by substrate-product analogues.
Bioorg Med Chem Lett
; 24(5): 1432-6, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24507924
20.
Inhibition of serine and proline racemases by substrate-product analogues.
Bioorg Med Chem Lett
; 24(1): 390-3, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24314397