Detalhe da pesquisa
1.
Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted Mycobacterium abscessus isolates.
Proc Natl Acad Sci U S A
; 121(17): e2403206121, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38630725
2.
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Nucleic Acids Res
; 48(14): 8099-8112, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32602532
3.
2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner.
Int J Mol Sci
; 23(6)2022 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328372
4.
Deletion of MSMEG_1350 in Mycobacterium smegmatis causes loss of epoxy-mycolic acids, fitness alteration at low temperature and resistance to a set of mycobacteriophages.
Microbiology (Reading)
; 164(12): 1567-1582, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30311878
5.
Covalent modifications of polysaccharides in mycobacteria.
Nat Chem Biol
; 14(3): 193-198, 2018 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29443974
6.
Mechanical morphotype switching as an adaptive response in mycobacteria.
Sci Adv
; 10(1): eadh7957, 2024 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170768
7.
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.
J Biol Chem
; 287(46): 38434-41, 2012 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23002234
8.
Mutations in the essential FAS II ß-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii.
Mol Microbiol
; 86(3): 568-79, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22994892
9.
Clinically relevant mutations in the PhoR sensor kinase of host-adapted Mycobacterium abscessus isolates impact response to acidic pH and virulence.
Microbiol Spectr
; 11(6): e0158823, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874174
10.
Acylation of glycerolipids in mycobacteria.
Nat Commun
; 14(1): 6694, 2023 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37872138
11.
Unveiling the Biosynthetic Pathway for Short Mycolic Acids in Nontuberculous Mycobacteria: Mycobacterium smegmatis MSMEG_4301 and Its Ortholog Mycobacterium abscessus MAB_1915 Are Essential for the Synthesis of α'-Mycolic Acids.
Microbiol Spectr
; 10(4): e0128822, 2022 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862962
12.
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
ACS Infect Dis
; 8(2): 296-309, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35037462
13.
Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus.
Front Microbiol
; 12: 706207, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34335541
14.
Unique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium.
Front Microbiol
; 12: 743126, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34777289
15.
Stepwise pathogenic evolution of Mycobacterium abscessus.
Science
; 372(6541)2021 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33926925
16.
A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide.
Tuberculosis (Edinb)
; 112: 69-78, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30205971
17.
2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.
PLoS One
; 12(7): e0180925, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28749949
18.
IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages.
Int J Antimicrob Agents
; 43(1): 82-5, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139881
19.
Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.
Expert Rev Anti Infect Ther
; 11(4): 429-40, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23566152