Detalhe da pesquisa
1.
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Brain Behav Immun
; 119: 494-506, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38657842
2.
Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files.
Mol Divers
; 20(4): 789-803, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27631533
3.
Aggressive chemotherapy and the selection of drug resistant pathogens.
PLoS Pathog
; 9(9): e1003578, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068922
4.
The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi.
PLoS Biol
; 10(7): e1001368, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22870063
5.
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.
Parasitology
; 141(1): 37-49, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23611109
6.
Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.
Cell Mol Gastroenterol Hepatol
; 17(1): 29-40, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37703945
7.
Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file.
Mol Divers
; 17(2): 319-35, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23559278
8.
Influence of climate on malaria transmission depends on daily temperature variation.
Proc Natl Acad Sci U S A
; 107(34): 15135-9, 2010 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20696913
9.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system.
Neurosci Biobehav Rev
; 149: 105155, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37019248
10.
Multi-omic underpinnings of epigenetic aging and human longevity.
Nat Commun
; 14(1): 2236, 2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37076473
11.
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.
Nat Aging
; 3(8): 1020-1035, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37550455
12.
Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder.
Biol Psychiatry
; 93(4): 331-341, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36182531
13.
Complex effects of temperature on mosquito immune function.
Proc Biol Sci
; 279(1741): 3357-66, 2012 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22593107
14.
Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.
Proc Biol Sci
; 279(1747): 4677-85, 2012 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015626
15.
Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy.
J Chem Inf Model
; 52(11): 2937-49, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23062111
16.
PCSK9 Base Editing Therapeutics and Ischemic Stroke.
ACS Chem Neurosci
; 13(23): 3210-3212, 2022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36374568
17.
Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function.
J Am Coll Cardiol
; 80(7): 653-662, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35953131
18.
Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study.
J Am Heart Assoc
; 11(21): e026122, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36285785
19.
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Bioorg Med Chem Lett
; 21(21): 6596-602, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21920751
20.
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Bioorg Med Chem Lett
; 21(21): 6591-5, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955944