Detalhe da pesquisa
1.
Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors.
ACS Chem Biol
; 19(1): 173-184, 2024 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38193430
2.
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
J Med Chem
; 66(15): 10617-10627, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467168
3.
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
J Med Chem
; 66(8): 5892-5906, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026591
4.
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.
J Med Chem
; 65(12): 8191-8207, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653645
5.
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
J Med Chem
; 65(12): 8169-8190, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657291
6.
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Sci Rep
; 12(1): 18633, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36329085
7.
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
J Med Chem
; 64(16): 12304-12321, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34384024
8.
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.
J Med Chem
; 64(23): 17079-17097, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34846884
9.
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J Med Chem
; 63(8): 4047-4068, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275432
10.
Discovery and optimization of highly ligand-efficient oxytocin receptor antagonists using structure-based drug design.
Bioorg Med Chem Lett
; 19(3): 990-4, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095447
11.
Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist.
Bioorg Med Chem Lett
; 19(2): 528-32, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19081251
12.
Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.
Bioorg Med Chem Lett
; 19(3): 684-7, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19128969
13.
Theoretical study on the selectivity of asymmetric sulfur ylide epoxidation reaction.
Org Lett
; 6(15): 2559-62, 2004 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15255690
14.
Sulfonium ylide epoxidation reactions: methylene transfer.
Chem Commun (Camb)
; (9): 1076-7, 2004 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15116192