RESUMO
We report the first case of a massive accidental overdose of nevirapine in a 1-week newborn, due to confusion between nevirapine (Viramune) and nelfinavir (Viracept). The drug was eliminated spontaneously and quickly. We only observed mild neutropenia and hyperlactatemia, which regressed on its own without any clinical complication. Despite the good evolution of this massive overdose, physicians should be aware of confusion risks between some antiretroviral drugs.
Assuntos
Fármacos Anti-HIV/intoxicação , Infecções por HIV/tratamento farmacológico , Nevirapina/intoxicação , Overdose de Drogas , Feminino , Inibidores da Protease de HIV/uso terapêutico , Humanos , Recém-Nascido , Erros de Medicação , Nelfinavir/uso terapêuticoRESUMO
We describe a case of nosocomial maternal transmission of Bordetella pertussis to a very-low-birth-weight (VLBW) neonate in whom treatment was unsuccessful. This case underscores the need for rapid and sensitive PCR diagnosis in VLBW neonates and in parents with clinical signs of pertussis and suggests that standard treatment may not be appropriate for VLBW neonates.