Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex.

Human experience is imbued by the sense of being an embodied agent. The investigation of such basic self-consciousness has been hampered by the difficulty of comprehensively modulating it in the laboratory while reliably capturing ensuing subjective changes. The present preregistered study fills this gap by combining advanced meditative states with principled phenomenological interviews: 46 long-term meditators (19 female, 27 male) were instructed to modulate and attenuate their embodied self-experience during magnetoencephalographic monitoring. Results showed frequency-specific (high-beta band) activity reductions in frontoparietal and posterior medial cortices (PMC). Importantly, PMC reductions were driven by a subgroup describing radical embodied self-disruptions, including suspension of agency and dissolution of a localized first-person perspective. Neural changes were correlated with lifetime meditation and interview-derived experiential changes, but not with classical self-reports. The results demonstrate the potential of integrating in-depth first-person methods into neuroscientific experiments. Furthermore, they highlight neural oscillations in the PMC as a central process supporting the embodied sense of self.

Enhanced declarative memory in long-term mindfulness practitioners.

OBJECTIVES: Mindfulness meditation (MM) practice is considered to benefit physical and mental health. In particular, several studies have shown a beneficial effect of MM practice on memory performance. However, it is still not clear how long-term training affects long-term declarative memory. In this study we aimed to examine whether long-term MM training impacts declarative memory formation for diverse memoranda types, as well as the role of trait mindfulness, and the possible mediating role of anxiety. METHODS: We examined long-term memory performance in 23 experienced MM practitioners and 22 meditation-naïve age-matched individuals, by administering a variety of declarative memory tests, ranging from item recognition to narrative and autobiographical memory recollection and future projection. The participants also filled the Five Facet Mindfulness Questionnaire (FFMQ) and State-Trait Anxiety Inventory (STAI). RESULTS: Compared to the control group, long-term MM practitioners exhibited heightened memory performance for the picture recognition test and experienced enhanced vividness during autobiographic memory retrieval and future simulations. We also report a significant trait mindfulness and memory performance correlation, stemming exclusively from the Mm group. CONCLUSIONS: Our findings extend previous reports of the beneficial effect of a short-term MM training on memory performance, by showing the beneficial effect of long-term training on declarative memory. We also provide initial evidence that trait mindfulness is positively correlated with declarative memory performance, as a function of MM practice, and discuss these findings in light of the role of self-mode and cognitive diffusion, as well as attention and emotion.

Age-related functional connectivity along the hippocampal longitudinal axis.

Accumulated evidence points toward a long-axis functional division of the hippocampus, with its anterior part primarily associated with emotional processes and the posterior with navigation and cognition. It is yet unclear, however, how functional connectivity between areas along the hippocampal longitudinal axis and other brain regions differ, and how they are affected by age. Applying an anatomically driven general linear model-based functional connectivity analysis on a large database of resting-state fMRI data, we demonstrate that independent of age, the posterior hippocampus is functionally connected primarily with sensory and motor areas, the middle hippocampus with the default mode network, and the anterior with limbic and prefrontal regions. Along with an age-related disintegration of intra-hippocampal BOLD signal uniformity, the middle and posterior sub-regions exhibit mostly decreases in their functional connectivity with cortical regions, whereas the anterior hippocampus and ventral striatum appear to become more synchronized with age. These findings indicate that long-axis hippocampal areas are tuned to particular functional networks, which do not age in a unified manner.

Inter-participant consistency of language-processing networks during abstract thoughts.

Human brain imaging typically employs structured and controlled tasks to avoid variable and inconsistent activation patterns. Here we expand this assumption by showing that an extremely open-ended, high-level cognitive task of thinking about an abstract content, loosely defined as "abstract thinking" - leads to highly consistent activation maps. Specifically, we show that activation maps generated during such cognitive process were precisely located relative to borders of well-known networks such as internal speech, visual and motor imagery. The activation patterns allowed decoding the thought condition at >95%. Surprisingly, the activated networks remained the same regardless of changes in thought content. Finally, we found remarkably consistent activation maps across individuals engaged in abstract thinking. This activation bordered, but strictly avoided visual and motor networks. On the other hand, it overlapped with left lateralized language networks. Activation of the default mode network (DMN) during abstract thought was similar to DMN activation during rest. These observations were supported by a quantitative neuronal distance metric analysis. Our results reveal that despite its high level, and varied content nature - abstract thinking activates surprisingly precise and consistent networks in participants' brains.

Alterations in task-induced activity and resting-state fluctuations in visual and DMN areas revealed in long-term meditators.

Recently we proposed that the information contained in spontaneously emerging (resting-state) fluctuations may reflect individually unique neuro-cognitive traits. One prediction of this conjecture, termed the "spontaneous trait reactivation" (STR) hypothesis, is that resting-state activity patterns could be diagnostic of unique personalities, talents and life-styles of individuals. Long-term meditators could provide a unique experimental group to test this hypothesis. Using fMRI we found that, during resting-state, the amplitude of spontaneous fluctuations in long-term mindfulness meditation (MM) practitioners was enhanced in the visual cortex and significantly reduced in the DMN compared to naïve controls. Importantly, during a visual recognition memory task, the MM group showed heightened visual cortex responsivity, concomitant with weaker negative responses in Default Mode Network (DMN) areas. This effect was also reflected in the behavioral performance, where MM practitioners performed significantly faster than the control group. Thus, our results uncover opposite changes in the visual and default mode systems in long-term meditators which are revealed during both rest and task. The results support the STR hypothesis and extend it to the domain of local changes in the magnitude of the spontaneous fluctuations.

Coupling between pupil fluctuations and resting-state fMRI uncovers a slow build-up of antagonistic responses in the human cortex.

Even in absence of overt tasks, the human cortex manifests rich patterns of spontaneous "resting state" BOLD-fMRI fluctuations. However, the link of these spontaneous fluctuations to behavior is presently unclear. Attempts to directly investigate this link invariably lead to disruptions of the resting state. Here we took advantage of the well-established association between pupil diameter and attentional gain to address this issue by examining the correlation between the resting state BOLD and pupil fluctuations. Our results uncover a spontaneously emerging spatiotemporal pupil-BOLD correlation whereby a slow buildup of activity in default mode areas preceded both pupil dilation and wide-spread BOLD suppression in sensorimotor cortex. Control experiments excluded a role for luminance fluctuations or fixation. Comparing the pupil-correlated patterns to activation maps during visual imagery revealed a substantial overlap. Our results indicate a link between behavior, as indexed by pupil diameter, and resting state BOLD fluctuations. These pupil dilations, assumed to be related to attentional gain, were associated with spontaneously emerging antagonism between fundamental cortical networks.

How does it feel to lack a sense of boundaries? A case study of a long-term mindfulness meditator.

This paper discusses the phenomenological nature of the sense of boundaries (SB), based on the case of S, who has practiced mindfulness in the Satipathana and Theravada Vipassana traditions for about 40years and accumulated around 20,000h of meditative practice. S's unique abilities enable him to describe his inner lived experience with great precision and clarity. S was asked to shift between three different stages: (a) the default state, (b) the dissolving of the SB, and (c) the disappearance of the SB. Based on his descriptions, we identified seven categories (with some overlap) that alter during the shifts between these stages, including the senses of: (1) internal versus external, (2) time, (3) location, (4) self, (5) agency (control), (6) ownership, and (7) center (first-person-egocentric-bodily perspective). Two other categories, the touching/touched structure and one's bodily feelings, do not fade away completely even when the sense-of-boundaries disappears.

Resting state functional connectivity reflects abnormal task-activated patterns in a developmental object agnosic.

Even in the absence of stimulation or task, the cerebral cortex shows an incessant pattern of ultra slow fluctuations which are coherent across brain regions. In the healthy brain these coherent patterns (also termed resting state functional connectivity) often exhibit spatial similarity to the large scale organization of task-induced functional networks. However, it is not clear to what extent the resting state patterns can also reflect task-induced abnormalities in cortical activations which are often detected in various brain pathologies. Here we examined whether an abnormal visual activation pattern is recapitulated in the resting state functional connectivity. We examined LG, a sighted young adult with developmental object agnosia and no apparent cortical structural abnormality. We have previously reported that upon visual stimulation, LG's intermediate visual areas (V2, V3) are paradoxically deactivated. Here, examining LG's resting state functional connectivity revealed the same pattern of functional abnormality - including a strong atypical decorrelation between areas V2-V3 and the rest of the visual system. Thus, our results suggest that resting-state functional connectivity could provide a powerful tool which could complement task-specific paradigms in detecting task-related abnormalities in cortical activity without resorting to task performance.

Situational assessment of empathy and compassion: Predicting prosociality using a video-based task.

Classical psychometric approaches in social science measure individuals' tendency to experience empathy and compassion. Using abstract questionnaire items, they place high demand on subjects' capacity to introspect, memorize, and generalize the corresponding emotions. We employed a Socio-affective Video Task (SoVT)-an alternative approach that measures situationally elicited emotions-and assessed its predictive power over prosocial behavior against classical questionnaires in a sample of Israeli university students. We characterized the conceptual embedding of the SoVT concerning other measures of prosocial affect and cognition, and tested group identification as an alternative precursor to prosocial behavior. Eighty participants rated their reactions to videos that presented the suffering of others or everyday scenes on scales of negative affect (providing a proxy for elicited empathy) and compassion. We then administered classical questionnaires that target empathy (the Interpersonal Reactivity Index) and compassion (the Compassionate Love Scale), as well as measures of hypothetical and real-life helping and prosocial attitudes-including conflict attitudes and intergroup bias. While compassion ratings in the SoVT failed to predict prosociality more accurately than classical questionnaires, the SoVT empathy index succeeded and correlated strongly with other precursors of prosociality. These results support video-based situational assessment as an implicit and robust alternative in the measurement of empathy-related processes.

Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment.

Introduction: Despite an emerging understanding regarding the pivotal mechanistic role of subjective experiences that unfold during acute psychedelic states, very little has been done in the direction of better characterizing such experiences and determining their long-term impact. The present paper utilizes two cross-sectional studies for spotlighting - for the first time in the literature - the characteristics and outcomes of self-reported past experiences related to one's subjective sense of death during ayahuasca ceremonies, termed here Ayahuasca-induced Personal Death (APD) experiences. Methods: Study 1 (n = 54) reports the prevalence, demographics, intensity, and impact of APDs on attitudes toward death, explores whether APDs are related with psychopathology, and reveals their impact on environmental concerns. Study 2 is a larger study (n = 306) aiming at generalizing the basic study 1 results regarding APD experience, and in addition, examining whether APDs is associated with self-reported coping strategies and values in life. Results: Our results indicate that APDs occur to more than half of those participating in ayahuasca ceremonies, typically manifest as strong and transformative experiences, and are associated with an increased sense of transcending death (study 1), as well as the certainty in the continuation of consciousness after death (study 2). No associations were found between having undergone APD experiences and participants' demographics, personality type, and psychopathology. However, APDs were associated with increased self-reported environmental concern (study 1). These experiences also impact life in profound ways. APDs were found to be associated with increases in one's self-reported ability to cope with distress-causing life problems and the sense of fulfillment in life (study 2). Discussion: The study's findings highlight the prevalence, safety and potency of death experiences that occur during ayahuasca ceremonies, marking them as possible mechanisms for psychedelics' long-term salutatory effects in non-clinical populations. Thus, the present results join other efforts of tracking and characterizing the profound subjective experiences that occur during acute psychedelic states.

The (In)flexible self: Psychopathology, mindfulness, and neuroscience.

Clinical and neuroscientific evidence indicates that transdiagnostic processes contribute to the generation and maintenance of psychopathological symptoms and disorders. Rigidity (inflexibility) appears a core feature of most transdiagnostic pathological processes. Decreasing rigidity may prove important to restore and maintain mental health. One of the primary domains in which rigidity and flexibility plays a role concerns the self. We adopt the pattern theory of self (PTS) for a working definition of self. This incorporates the pluralist view on self as constituted by multiple aspects or processes, understood to constitute a self-pattern, i.e. processes organized in non-linear dynamical relations across a number of time scales. The use of mindfulness meditation in the format of Mindfulness Based Interventions (MBIs) has been developed over four decades in Clinical Psychology. MBIs are promising as evidence-based treatments, shown to be equivalent to gold-standard treatments and superior to specific active controls in several randomized controlled trials. Notably, MBIs have been shown to target transdiagnostic symptoms. Given the hypothesized central role of rigid, habitual self-patterns in psychopathology, PTS offers a useful frame to understand how mindfulness may be beneficial in decreasing inflexibility. We discuss the evidence that mindfulness can alter the psychological and behavioral expression of individual aspects of the self-pattern, as well as favour change in the self-pattern as a whole gestalt. We discuss neuroscientific research on how the phenomenology of the self (pattern) is reflected in associated cortical networks and meditation-related alterations in cortical networks. Creating a synergy between these two aspects can increase understanding of psychopathological processes and improve diagnostic and therapeutic options.

Self-Boundary Dissolution in Meditation: A Phenomenological Investigation.

A fundamental aspect of the sense of self is its pre-reflective dimension specifying the self as a bounded and embodied knower and agent. Being a constant and tacit feature structuring consciousness, it eludes robust empirical exploration. Recently, deep meditative states involving global dissolution of the sense of self have been suggested as a promising path for advancing such an investigation. To that end, we conducted a comprehensive phenomenological inquiry into meditative self-boundary alteration. The induced states were systematically characterized by changes in six experiential features including the sense of location, agency, first-person perspective, attention, body sensations, and affective valence, as well as their interaction with meditative technique and overall degree of dissolution. Quantitative analyses of the relationships between these phenomenological categories highlighted a unitary dimension of boundary dissolution. Notably, passive meditative gestures of "letting go", which reduce attentional engagement and sense of agency, emerged as driving the depth of dissolution. These findings are aligned with an enactive approach to the pre-reflective sense of self, linking its generation to sensorimotor activity and attention-demanding processes. Moreover, they set the stage for future phenomenologically informed analyses of neurophysiological data and highlight the utility of combining phenomenology and intense contemplative training for a scientific characterization of processes giving rise to the basic sense of being a bounded self.

Effects of a Mindfulness Intervention Among Arab Teachers Are Mediated by Decentering: A Pilot Study.

Although mindfulness-based interventions (MBIs) in education are widely spreading in the world, examination of mindfulness effects in Arab schools is still scarce. This pilot study aimed to fill this gap by examining the effects of an MBI among Arab teachers in Israel. This examination was conducted within the framework of the mindful self in school relationships (MSSR) model, which suggests that the positive effects of MBI on teachers' emotion regulation are mediated by decentering. The participants (N = 39) were teachers from two Arab elementary schools in Israel, who underwent an MBI course (the MBI condition, N = 20) and another cognitive intervention (the control condition, N = 19). In a pre-post design, participants completed mindfulness, decentering, emotion regulation, and stress questionnaires. We hypothesized that (1) only in the MBI group, teachers' mindfulness, decentering, and emotional regulation will increase and stress will decrease, and (2) changes in teachers' decentering would mediate the associations of changes in teachers' mindfulness with changes in their emotion regulation. ANOVA analyses show that, only in the MBI condition, teachers showed an increase in three mindfulness subscales (acting with awareness, non-reactivity, and observance), in decentering, and in adaptive emotion regulation (reappraisal) and a decrease in stress. Furthermore, changes from pre-intervention to post-intervention in teachers' decentering mediated the associations of their pre-post changes in mindfulness with changes in emotion regulation. This study provides initial support to the feasibility and efficacy of MBI among Israeli Arab teachers and suggests decentering as a potential mediator of its effects in initial support of the MSSR model.

The Hitchhiker's Guide to Neurophenomenology - The Case of Studying Self Boundaries With Meditators.

This paper is a practical guide to neurophenomenology. Varela's neurophenomenological research program (NRP) aspires to bridge the gap between, and integrate, first-person (1P) and third-person (3P) approaches to understanding the mind. It does so by suggesting a methodological framework allowing these two irreducible phenomenal domains to relate and reciprocally support the investigation of one another. While highly appealing theoretically, neurophenomenology invites researchers to a challenging methodological endeavor. Based on our experience with empirical neurophenomenological implementation, we offer practical clarifications and insights learnt along the way. In the first part of the paper, we outline the theoretical principles of the NRP and briefly present the field of 1P research. We speak to the importance of phenomenological training and outline the utility of cooperating with meditators as skilled participants. We suggest that 1P accounts of subjective experience can be placed on a complexity continuum ranging between thick and thin phenomenology, highlighting the tension and trade-off inherent to the neurophenomenological attempt to naturalize phenomenology. We then outline a typology of bridges, which create mutual constraints between 1P and 3P approaches, and argue for the utility of alternating between the bridges depending on the available experimental resources, domain of interest and level of sought articulation. In the second part of the paper, we demonstrate how the theory can be put into practice by describing a decade of neurophenomenological studies investigating the sense of self with increasing focus on its embodied, and minimal, aspects. These aspects are accessed via the dissolution of the sense-of-boundaries, shedding new light on the multi-dimensionality and flexibility of embodied selfhood. We emphasize the evolving neurophenomenological dialogue, showing how consecutive studies, placed differently on the thin-to-thick 1P continuum, advance the research project by using the bridging principles appropriate for each stage.

When meditators avoid counting during time production things get interesting.

Time production (TP) with or without chronometric counting both instantiates and reflects the working of an internal clock, as originally posited by Treisman. We exploit the fact that a number of experienced meditators, who had previously participated in a study wherein TP was assessed, and who had employed chronometric counting then, would be coming back to the lab to participate in a second study. We specifically requested that they should not employ chronometric counting this time, thus allowing us to contrast TP with and without counting. We report a qualitative difference between TP implemented by counting and TP without counting: The first is a linear function of target duration (T), while the second is not, and entails a discontinuity in the function. Requesting meditators not to engage in chronometric counting, and thereby forcing them to rely instead on other cues (sensory, bodily, etc.), might well be an appropriate context in which to observe such a discontinuity in TP.

Contemplative neuroscience, self-awareness, and education.

Accumulating research in education shows that contemplative practices contribute to and foster well-being of individuals in sustainable ways. This bears special importance for teachers, as it affects not only them but also their students. Based on accumulating behavioral and neuroscientific findings, it has been suggested that a key process by which mindfulness meditation enhances self-regulation is the altering of self-awareness. Indeed, accumulated work shows that the underlying networks supporting various types of self-awareness are malleable following meditative practice. However, the field of education has developed independently from the study of the self and its relation to contemplative neuroscience thus far, and to date there is no systematic account linking this accumulating body of knowledge to the field of education or discussing how it might be relevant to teachers. Here we show how incorporating insights from contemplative neuroscience-which are built on the conceptualization and neuroscience of the self-into contemplative pedagogy can inform the field and might even serve as a core underlying mechanism tying together different empirical evidence. This review points to potential neural mechanisms by which mindfulness meditation helps teachers manage stress and promote supportive learning environments, resulting in improved educational outcomes, and thus it has significant implications for educational policy regarding teachers.

Individual EEG alpha profiles are gender-dependent and indicate subjective experiences in Whole-Body Perceptual Deprivation.

We use a unique environment of Whole Body Perceptual Deprivation (WBPD) to induce an altered state of consciousness (ASC) in our participants, and employ online EEG recording. We present individual EEG alpha profiles, and show how these data can be analyzed at the individual level. Our goal is to investigate to what degree subjective experience matches EEG alpha profile, and in particular, the various alpha hemispheric asymmetries observed in the frontal, parietal, and occipital lobes. Specifically, we consider positive (frontal L < R) or negative (frontal L > R) affect; a more verbal (L > R) or a more imagistic (R > L) mode of thinking; and a more trancelike (frontal > parietal) or more reflective (frontal < parietal) state of consciousness. Our results indicate that the individual alpha profiles are reflected in individual differences in subjective experience. However, the alpha profiles are confounded with the gender of the participant. Specifically, there is a predominant R > L asymmetry found for male participants, and a predominant L > R asymmetry found for female participants.

Fully immersed: State absorption and electrophysiological effects of the OVO Whole-Body Perceptual Deprivation chamber.

Absorption, the ability to highly focus attention, as well as openness to self-altering experiences, is an important psychological construct, closely related to deep-meditation states and other altered states of consciousness. Yet, little is known about the electrophysiological profile of states of absorption, possibly due to the difficulty to induce this state in the lab. While most studies have used a visual Ganzfeld (homogeneous perceptual field), here we use a novel technique of full immersion-the OVO Whole-Body Perceptual Deprivation (OVO-WBPD) chamber, which is an altered sensory environment in the form of a human-sized egg. Consequently, the aims of the current study were to investigate whether the OVO-WBPD chamber induces state absorption, using first-person reports, as well as to examine electrophysiological change following immersion in this altered sensory environment. Fourteen participants volunteered to participate in the study. Trait absorption was measured using the Tellegen Absorption Scale (TAS). State absorption was assessed by analyzing the content of the subjective reports, using sub-categories of the absorption construct (e.g., synesthesia). EEG was measured before and during a 20-min OVO-WBPD experience. Using exact low-resolution brain electromagnetic tomography (eLORETA), we analyzed change in oscillatory EEG activity and localized the generators of the scalp EEG power spectra following the OVO-WBPD. Our results show that OVO-WBPD immersion leads to a state of absorption in all participants. We also report significant increased oscillatory activity in the delta and beta bands, in the left inferior frontal cortex, with a peak in the sub-lobar of the left insula. In addition, a positive correlation was found between change in delta activity and trait absorption. The results are discussed in light of other meditative practices and altered states of consciousness.

Psychedelics, Meditation, and Self-Consciousness.

In recent years, the scientific study of meditation and psychedelic drugs has seen remarkable developments. The increased focus on meditation in cognitive neuroscience has led to a cross-cultural classification of standard meditation styles validated by functional and structural neuroanatomical data. Meanwhile, the renaissance of psychedelic research has shed light on the neurophysiology of altered states of consciousness induced by classical psychedelics, such as psilocybin and LSD, whose effects are mainly mediated by agonism of serotonin receptors. Few attempts have been made at bridging these two domains of inquiry, despite intriguing evidence of overlap between the phenomenology and neurophysiology of meditation practice and psychedelic states. In particular, many contemplative traditions explicitly aim at dissolving the sense of self by eliciting altered states of consciousness through meditation, while classical psychedelics are known to produce significant disruptions of self-consciousness, a phenomenon known as drug-induced ego dissolution. In this article, we discuss available evidence regarding convergences and differences between phenomenological and neurophysiological data on meditation practice and psychedelic drug-induced states, with a particular emphasis on alterations of self-experience. While both meditation and psychedelics may disrupt self-consciousness and underlying neural processes, we emphasize that neither meditation nor psychedelic states can be conceived as simple, uniform categories. Moreover, we suggest that there are important phenomenological differences even between conscious states described as experiences of self-loss. As a result, we propose that self-consciousness may be best construed as a multidimensional construct, and that "self-loss," far from being an unequivocal phenomenon, can take several forms. Indeed, various aspects of self-consciousness, including narrative aspects linked to autobiographical memory, self-related thoughts and mental time travel, and embodied aspects rooted in multisensory processes, may be differently affected by psychedelics and meditation practices. Finally, we consider long-term outcomes of experiences of self-loss induced by meditation and psychedelics on individual traits and prosocial behavior. We call for caution regarding the problematic conflation of temporary states of self-loss with "selflessness" as a behavioral or social trait, although there is preliminary evidence that correlations between short-term experiences of self-loss and long-term trait alterations may exist.