Detalhe da pesquisa
1.
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 30(13): 127197, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331932
2.
Microbial biotransformation - an important tool for the study of drug metabolism.
Xenobiotica
; 49(8): 877-886, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30118378
3.
Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622.
J Pharmacol Exp Ther
; 365(3): 556-566, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29563325
4.
Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 24(5): 1417-20, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24485781
5.
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.
Commun Biol
; 6(1): 649, 2023 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37337079
6.
Building a Culture of Medicinal Chemistry Knowledge Sharing.
J Med Chem
; 65(5): 3776-3785, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35192762
7.
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
ACS Chem Biol
; 17(9): 2595-2604, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044633
8.
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
ACS Med Chem Lett
; 12(4): 540-547, 2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33854701
9.
Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 20(8): 2538-41, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20346667
10.
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Bioorg Med Chem Lett
; 20(8): 2493-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20304642
11.
The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B.
J Am Chem Soc
; 130(41): 13778-89, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18798629
12.
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure.
J Pharmacol Exp Ther
; 324(1): 322-30, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967939
13.
MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate.
ACS Med Chem Lett
; 9(7): 652-656, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034595
14.
High-Throughput Agonist Shift Assay Development for the Analysis of M1-Positive Allosteric Modulators.
SLAS Discov
; 22(8): 1060-1066, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28426939
15.
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
J Med Chem
; 60(16): 6771-6780, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28418656
16.
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
J Med Chem
; 49(24): 6954-7, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125248
17.
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J Med Chem
; 45(12): 2388-409, 2002 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036349
18.
Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization.
Org Lett
; 4(7): 1201-4, 2002 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-11922818
19.
SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs).
Curr Top Med Chem
; 14(15): 1738-54, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25176125
20.
Novel M(1) allosteric ligands: a patent review.
Expert Opin Ther Pat
; 22(12): 1385-98, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23092292