Detalhe da pesquisa
1.
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Brain
; 145(12): 4349-4367, 2022 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36074904
2.
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg Med Chem Lett
; 30(3): 126751, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31862412
3.
Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.
Mol Ther
; 22(8): 1530-1543, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24832007
4.
Human metabolic phenotype diversity and its association with diet and blood pressure.
Nature
; 453(7193): 396-400, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18425110
5.
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J Med Chem
; 65(1): 562-578, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34939789
6.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J Med Chem
; 65(10): 7212-7230, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35536179
7.
Structural Analysis and Development of Notum Fragment Screening Hits.
ACS Chem Neurosci
; 13(13): 2060-2077, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35731924
8.
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Mol Neurodegener
; 16(1): 22, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823896
9.
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding.
SLAS Discov
; 26(2): 257-262, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808550
10.
Structural Insights into Notum Covalent Inhibition.
J Med Chem
; 64(15): 11354-11363, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292747
11.
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Elife
; 102021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33739284
12.
Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents.
J Proteome Res
; 9(5): 2255-64, 2010 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20092362
13.
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.
J Proteome Res
; 9(12): 6647-54, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20853909
14.
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
J Med Chem
; 63(21): 12942-12956, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33124429
15.
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J Med Chem
; 63(17): 9464-9483, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787107
16.
Biomarkers in nutritional epidemiology: applications, needs and new horizons.
Hum Genet
; 125(5-6): 507-25, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19357868
17.
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.
Anal Chem
; 81(13): 5119-29, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19489597
18.
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Medchemcomm
; 10(8): 1361-1369, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31534655
19.
Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.
Nat Genet
; 51(7): 1190, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31160811
20.
Molecular and functional variation in iPSC-derived sensory neurons.
Nat Genet
; 50(1): 54-61, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229984