Understanding protected area resilience: a multi-scale, social-ecological approach.

Protected areas (PAs) remain central to the conservation of biodiversity. Classical PAs were conceived as areas that would be set aside to maintain a natural state with minimal human influence. However, global environmental change and growing cross-scale anthropogenic influences mean that PAs can no longer be thought of as ecological islands that function independently of the broader social-ecological system in which they are located. For PAs to be resilient (and to contribute to broader social-ecological resilience), they must be able to adapt to changing social and ecological conditions over time in a way that supports the long-term persistence of populations, communities, and ecosystems of conservation concern. We extend Ostrom's social-ecological systems framework to consider the long-term persistence of PAs, as a form of land use embedded in social-ecological systems, with important cross-scale feedbacks. Most notably, we highlight the cross-scale influences and feedbacks on PAs that exist from the local to the global scale, contextualizing PAs within multi-scale social-ecological functional landscapes. Such functional landscapes are integral to understand and manage individual PAs for long-term sustainability. We illustrate our conceptual contribution with three case studies that highlight cross-scale feedbacks and social-ecological interactions in the functioning of PAs and in relation to regional resilience. Our analysis suggests that while ecological, economic, and social processes are often directly relevant to PAs at finer scales, at broader scales, the dominant processes that shape and alter PA resilience are primarily social and economic.

Requisite simplicities to help negotiate complex problems.

Decision makers responsible for natural resource management often complain that science delivers fragmented information that is not useful at the scale of implementation. We offer a way of negotiating complex problems by putting forward a requisite simplicity. A requisite simplicity attempts to discard some detail, while retaining conceptual clarity and scientific rigor, and helps us move to a new position where we can benefit from new knowledge. We illustrate the above using three case studies: elephant densities and vegetation change in a national park, the use of rules of thumb to support decision making in agriculture, and the management of salt in irrigation. We identify potential requisite simplicities that can allow us to generate new understanding, lead to action and provide opportunities for structured learning.

ncVarDB: a manually curated database for pathogenic non-coding variants and benign controls.

Variants within the non-coding genome are frequently associated with phenotypes in genome-wide association studies. These non-coding regions may be involved in the regulation of gene expression, encode functional non-coding RNAs, or influence splicing and other cellular functions. We have curated a list of characterized non-coding human genome variants based on the published evidence that indicates phenotypic consequences of the variation. In order to minimize annotation errors, two curators have independently verified the supporting evidence for pathogenicity of each non-coding variant in the published literature. The database consists of 721 non-coding variants linked to the published literature describing the evidence of functional consequences. We have also sampled 7228 covariate-matched benign controls, that have a population frequency of over 5%, from the single nucleotide polymorphism database (dbSNP151) database. These were sampled controlling for potential confounding factors such as linkage with pathogenic variants, annotation type (untranslated region, intron, intergenic, etc.) and variant type (substitution or indel). The dataset presented here represents a curated repository, with a potential use for the training or evaluation of algorithms used in the prediction of non-coding variant functionality. Database URL: https://github.com/Gardner-BinfLab/ncVarDB.

Finding Common Ground between Adaptive Management and Evidence-Based Approaches to Biodiversity Conservation.

Adaptive management (AM) and evidence-based conservation (EBC) have emerged as major decision-making frameworks for conservation management. AM deals with complexity and the importance of local context in making conservation decisions under conditions of high variability, uncertainty, and rapid environmental and social change. EBC seeks for generality from empirical data and aims to develop and enhance best practice. The goal of this review is to explore opportunities for finding common ground between AM and EBC. We propose a framework for distinguishing the subset of conservation problems that are amenable to an evidence-based approach, based on levels of uncertainty, complexity, and social agreement. We then suggest ways for combining multiple lines of evidence and developing greater opportunities for iteration and co-learning in EBC.