Detalhe da pesquisa
1.
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Mol Cell
; 64(5): 875-887, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889448
2.
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.
Biophys J
; 116(6): 1049-1063, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30846362
3.
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.
Proc Natl Acad Sci U S A
; 113(44): E6766-E6775, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791178
4.
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun
; 12(1): 1176, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608534
5.
HER2- and EGFR-specific affiprobes: novel recombinant optical probes for cell imaging.
Chembiochem
; 11(3): 345-50, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20052708
6.
PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity.
ACS Omega
; 5(1): 832-842, 2020 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31956834
7.
Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.
Bioorg Med Chem Lett
; 19(10): 2693-8, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362470
8.
The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Sci Signal
; 11(550)2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279169
9.
Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.
J Med Chem
; 50(8): 1978-82, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371004
10.
Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.
J Biomol Tech
; 18(4): 259-66, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17916799
11.
Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
J Med Chem
; 48(3): 764-72, 2005 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15689160
12.
Design and synthesis of 4-(alpha-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 src-homology 2 (Grb2 SH2) domain-binding peptides.
J Med Chem
; 48(16): 5369-72, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078854
13.
Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.
J Med Chem
; 48(12): 3945-8, 2005 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15943469
14.
Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.
Chem Biodivers
; 2(4): 447-56, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17191992
15.
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions.
Sci Rep
; 5: 15916, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522388
16.
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
J Med Chem
; 56(1): 182-200, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23259865
17.
Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids.
J Med Chem
; 52(6): 1612-8, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19226165
18.
Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist.
J Med Chem
; 51(23): 7459-68, 2008 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18989951
19.
Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.
J Org Chem
; 72(25): 9635-42, 2007 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17990895
20.
Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.
Org Biomol Chem
; 5(2): 367-72, 2007 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17205182