An open-source, low-cost voluntary running activity tracking tool for in vivo rodent studies.

In vivo rodent behavioral and physiological studies often benefit from measurement of general activity. However, many existing instruments necessary to track such activity are high in cost and invasive within home cages, some even requiring extensive separate cage systems, limiting their widespread use to collect data. We present here a low-cost open-source alternative that measures voluntary wheel running activity and allows for modulation and customization, along with a reproducible and easy to set-up code pipeline for setup and analysis in Arduino IDE and R. Our robust, non-invasive scalable voluntary running activity tracker utilizes readily accessible magnets, Hall effect sensors, and an Arduino microcontroller. Importantly, it can interface with existing rodent home cages and wheel equipment, thus eliminating the need to transfer the mice to an unfamiliar environment. The system was validated both for accuracy by a rotating motor used to simulate mouse behavior, and in vivo. Our recorded data is consistent with results found in the literature showing that the mice run between 3 to 16 kilometers per night, and accurately captures speed and distance traveled continuously on the wheel. Such data are critical for analysis of highly variable behavior in mouse models and allow for characterization of behavioral metrics such as general activity. This system provides a flexible, low-cost methodology, and minimizes the cost, infrastructure, and personnel required for tracking voluntary wheel activity.

A Review of Magnetic Elastomers and Their Role in Soft Robotics.

Soft robotics as a field of study incorporates different mechanisms, control schemes, as well as multifunctional materials to realize robots able to perform tasks inaccessible to traditional rigid robots. Conventional methods for controlling soft robots include pneumatic or hydraulic pressure sources, and some more recent methods involve temperature and voltage control to enact shape change. Magnetism was more recently introduced as a building block for soft robotic design and control, with recent publications incorporating magnetorheological fluids and magnetic particles in elastomers, to realize some of the same objectives present in more traditional soft robotics research. This review attempts to organize and emphasize the existing work with magnetism and soft robotics, specifically studies on magnetic elastomers, while highlighting potential avenues for further research enabled by these advances.