Detalhe da pesquisa
1.
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development.
Angew Chem Int Ed Engl
; 61(46): e202205858, 2022 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36115062
2.
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome.
Angew Chem Int Ed Engl
; 60(35): 19191-19200, 2021 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161644
3.
How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
J Chem Inf Model
; 59(5): 1897-1908, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31021613
4.
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 11(7): 511-7, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030728
5.
Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.
ACS Chem Biol
; 19(2): 563-574, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38232960
6.
Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 12(4): 304, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991088
7.
Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 11(9): 741, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284678
8.
Modulation of Host-Parasite Interactions with Small Molecules Targeting Schistosoma mansoni microRNAs.
ACS Infect Dis
; 8(10): 2028-2034, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098656
9.
Lipid-protein nanodiscs as reference medium in detergent screening for high-resolution NMR studies of integral membrane proteins.
J Am Chem Soc
; 132(16): 5628-9, 2010 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356311
10.
NMR structural and dynamical investigation of the isolated voltage-sensing domain of the potassium channel KvAP: implications for voltage gating.
J Am Chem Soc
; 132(16): 5630-7, 2010 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356312
11.
Time efficient detection of protein-ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment.
J Biomol NMR
; 43(4): 211-7, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19205897
12.
NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Top Curr Chem
; 273: 1-14, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-23605457
13.
Modulation of the Bioactive Conformation of Transforming Growth Factor ß: Possible Implications of Cation Binding for Biological Function.
Top Curr Chem
; 273: 155-81, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-23605462
14.
Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy.
Angew Chem Int Ed Engl
; 49(41): 7504-7, 2010 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20809556
15.
Design of small molecule libraries for NMR screening and other applications in drug discovery.
Curr Top Med Chem
; 3(1): 11-23, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570776
16.
Second-site NMR screening and linker design.
Curr Top Med Chem
; 3(1): 69-80, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570778
17.
Direct Measurement of Dihedral Angles with High-Resolution NMR Spectroscopy.
Angew Chem Int Ed Engl
; 37(4): 456-458, 1998 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711156
18.
Lipid-protein nanoscale bilayers: a versatile medium for NMR investigations of membrane proteins and membrane-active peptides.
J Am Chem Soc
; 130(7): 2140-1, 2008 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18229924
19.
Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution.
Angew Chem Int Ed Engl
; 46(11): 1864-8, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17274084
20.
Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations.
Mol Cancer Ther
; 11(8): 1747-57, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22653967