Detalhe da pesquisa
1.
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system.
J Cell Sci
; 136(6)2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825945
2.
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Biochim Biophys Acta Mol Cell Res
; 1864(1): 217-230, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27818272
3.
The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.
J Biol Chem
; 290(27): 16502-16, 2015 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25957407
4.
Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council.
Eur J Neurosci
; 49(11): 1362-1370, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30673123
5.
Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.
iScience
; 27(6): 109609, 2024 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38827406
6.
Dementia research in Ireland: What should we prioritise?
HRB Open Res
; 6: 12, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37954094
7.
Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.
J Biol Chem
; 285(48): 37415-26, 2010 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864542
8.
Acetyl-leucine slows disease progression in lysosomal storage disorders.
Brain Commun
; 3(1): fcaa148, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738443
9.
Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.
J Clin Med
; 9(4)2020 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32276303
10.
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
J Neurosci
; 28(27): 6926-37, 2008 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18596167
11.
No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer's disease.
Respir Physiol Neurobiol
; 265: 55-67, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29969703
12.
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.
J Neurochem
; 107(1): 35-49, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18715269
13.
Neprilysin degrades murine Amyloid-ß (Aß) more efficiently than human Aß: Further implication for species-specific amyloid accumulation.
Neurosci Lett
; 686: 74-79, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30144539
14.
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Nat Rev Drug Discov
; 17(9): 660-688, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30116051
15.
Neuronal macroautophagy: from development to degeneration.
Mol Aspects Med
; 27(5-6): 503-19, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16999991
16.
Bridging the age spectrum of neurodegenerative storage diseases.
Best Pract Res Clin Endocrinol Metab
; 29(2): 127-43, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987168
17.
Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L.
Neurobiol Aging
; 25(1): 83-91, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14675734
18.
beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase.
Neurobiol Aging
; 24(1): 179-86, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12493564
19.
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
J Cell Biol
; 199(5): 723-34, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23185029
20.
Role of aromatic side chains in amyloid ß-protein aggregation.
ACS Chem Neurosci
; 3(12): 1008-16, 2012 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23259036