Detalhe da pesquisa
1.
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Brain
; 147(5): 1784-1798, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387080
2.
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
J Pharmacol Exp Ther
; 357(2): 423-31, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26907621
3.
Adverse health outcomes in women exposed in utero to diethylstilbestrol.
N Engl J Med
; 365(14): 1304-14, 2011 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21991952
4.
Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.
Bioorg Med Chem Lett
; 21(21): 6348-52, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955943
5.
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Bioorg Med Chem Lett
; 20(10): 3120-4, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20443228
6.
1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Bioorg Med Chem Lett
; 20(10): 3125-8, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400309
7.
Label-free, High-Resolution Optical Metabolic Imaging of Human Cervical Precancers Reveals Potential for Intraepithelial Neoplasia Diagnosis.
Cell Rep Med
; 1(2)2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32577625
8.
Irritable bowel syndrome: more than abdominal pain and bowel habit abnormalities.
Clin Gastroenterol Hepatol
; 7(1): 73-9, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19124114
9.
Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
J Pharmacol Exp Ther
; 330(1): 191-7, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19349522
10.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631533
11.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19539468
12.
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4088-91, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19540112
13.
Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure.
Circ Res
; 93(1): 69-76, 2003 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12791709
14.
Changes in the Chemical Composition and Decay Resistance of Thermally-Modified Hevea brasiliensis Wood.
PLoS One
; 11(3): e0151353, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26986200
15.
Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects.
DNA Cell Biol
; 24(7): 410-31, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16008510
16.
Quantitative analysis of gene transcription in stroke models using real-time RT-PCR.
Methods Mol Med
; 104: 265-84, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15454673
17.
A standard operating procedure for assessing liquid handler performance in high-throughput screening.
J Biomol Screen
; 7(6): 554-69, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14599354
18.
The quantification of gene expression in an animal model of brain ischaemia using TaqMan real-time RT-PCR.
Brain Res Mol Brain Res
; 106(1-2): 101-16, 2002 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12393270
19.
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
J Med Chem
; 53(18): 6653-80, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726512
20.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20196613