RESUMO
The transition metal-catalysed direct functionalisation of C-H bonds is an increasingly viable alternative to the multi-step strategies traditionally adopted. The use of powerful and environmentally benign gold(I) and gold(III) catalysts in such transformations has highlighted their remarkable reactivity and led to a significant increase in their utilisation. This tutorial review provides an overview of gold-catalysed C-H functionalisation, looking at transformations which rely on the ability of gold to perform C-H activation, as well as those exploiting its potent π-acidity.
RESUMO
We demonstrate the first Au(I)-mediated C-H activation of arenes. Au(I) salts undergo C-H activation with electron-poor arenes, in stark contrast to Au(III) salts, which activate electron-rich arenes. This operationally simple and highly regioselective process occurs under very mild conditions and gives access to a variety of Au(I)-arene complexes in excellent yields.
Assuntos
Carbono/química , Ouro/química , Hidrocarbonetos Aromáticos/química , Hidrogênio/química , Catálise , Elétrons , Modelos Moleculares , Conformação MolecularRESUMO
The heteroleptic calcium amides [{ArNC(Me)CHC(Me)NAr}Ca(NR(2))(THF)] (Ar=2,6-di-iso-propylphenyl, R=SiMe(3), Ph) and the homoleptic heavier alkaline earth amides, [M{N(SiMe(3))(2)}(2)] (M=Ca, Sr and Ba) are reported as pre-catalysts for the hydroamination of isocyanates.