Detalhe da pesquisa
1.
Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite.
Drug Metab Dispos
; 48(12): 1312-1320, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978223
2.
Pharmacodynamics, pharmacokinetics and safety of revefenacin (TD-4208), a long-acting muscarinic antagonist, in patients with chronic obstructive pulmonary disease (COPD): Results of two randomized, double-blind, phase 2 studies.
Pulm Pharmacol Ther
; 48: 71-79, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28987804
3.
A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19.
Eur Respir J
; 58(4)2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210790
4.
Biotransformation and bioactivation reactions of alicyclic amines in drug molecules.
Drug Metab Rev
; 46(3): 379-419, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24909234
5.
Hepatic Dysfunction Quantified by HepQuant DuO Outperforms Child-Pugh Classification in Predicting the Pharmacokinetics of Ampreloxetine.
Clin Pharmacol Ther
; 116(1): 186-193, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38654484
6.
Efficacy and safety of an inhaled pan-Janus kinase inhibitor, nezulcitinib, in hospitalised patients with COVID-19: results from a phase 2 clinical trial.
BMJ Open Respir Res
; 10(1)2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37460276
7.
Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat.
J Pharmacol Exp Ther
; 341(1): 137-45, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22235148
8.
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species.
Toxicol Sci
; 186(2): 323-337, 2022 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35134999
9.
Population Pharmacokinetics of Revefenacin in Patients with Chronic Obstructive Pulmonary Disease.
Clin Pharmacokinet
; 60(3): 391-401, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33124005
10.
Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain.
Clin Pharmacokinet
; 60(1): 121-131, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32856281
11.
Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID-19.
Clin Transl Sci
; 14(6): 2556-2565, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34318597
12.
Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials.
Drug Saf
; 44(6): 619-634, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33725335
13.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Drug Metab Dispos
; 38(11): 1954-61, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20693416
14.
Safety, Pharmacokinetics, and Pharmacodynamics of TD-0714, a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects.
Clin Transl Sci
; 13(6): 1307-1315, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32506827
15.
Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study.
Clin Pharmacol Drug Dev
; 9(1): 130-139, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31468714
16.
Pharmacokinetics and safety of revefenacin in subjects with impaired renal or hepatic function.
Int J Chron Obstruct Pulmon Dis
; 14: 2305-2318, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31632000
17.
Mechanisms underlying saturable intestinal absorption of metformin.
Drug Metab Dispos
; 36(8): 1650-8, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18458049
18.
Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
Clin Pharmacol Ther
; 104(5): 916-932, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137645
19.
Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine.
J Med Chem
; 47(11): 2935-8, 2004 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15139772
20.
Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
J Med Chem
; 56(20): 8163-82, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24069953