Detalhe da pesquisa
1.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Proc Natl Acad Sci U S A
; 116(36): 17990-18000, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439820
2.
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Br J Cancer
; 124(3): 616-627, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33173151
3.
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Int J Cancer
; 142(10): 2139-2152, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243224
4.
Targeting the ribosome to treat multiple myeloma.
Mol Ther Oncol
; 32(1): 200771, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38596309
5.
ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
Sci Adv
; 10(10): eadj8803, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457494
6.
Harnessing the Nucleolar DNA Damage Response in Cancer Therapy.
Genes (Basel)
; 12(8)2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34440328
7.
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.
Signal Transduct Target Ther
; 6(1): 323, 2021 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462428
8.
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Nat Commun
; 11(1): 2641, 2020 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32457376
9.
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Commun Biol
; 2: 39, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30701204
10.
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Cancer Discov
; 9(8): 1036-1049, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092402