Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802943
3.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
4.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(3): 1094-9, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20031401
5.
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Bioorg Med Chem Lett
; 20(3): 1100-5, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022747
6.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J Med Chem
; 63(22): 13796-13824, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170686
7.
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4042-5, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553107
8.
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Bioorg Med Chem Lett
; 19(15): 4191-5, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19540115
9.
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4196-200, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541484
10.
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(23): 6083-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18930398