Detalhe da pesquisa
1.
Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT.
Blood
; 133(9): 978-989, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30573633
2.
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
Bioorg Med Chem Lett
; 29(14): 1737-1745, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31122869
3.
Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4.
Blood
; 124(15): 2442-9, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25150299
4.
Anti-protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis.
Blood
; 121(15): 2821-7, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23325832
5.
Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4.
Blood
; 122(2): 272-81, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673861
6.
Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes.
Blood
; 120(16): 3345-52, 2012 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22942185
7.
Anilinotriazoles as potent gamma secretase modulators.
Bioorg Med Chem Lett
; 24(24): 5805-5813, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25454273
8.
Vaccination with anti-idiotype antibody ganglidiomab mediates a GD(2)-specific anti-neuroblastoma immune response.
Cancer Immunol Immunother
; 62(6): 999-1010, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591980
9.
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Bioorg Med Chem Lett
; 23(17): 4794-800, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23890837
10.
Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.
Eur J Med Chem
; 228: 114028, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34920170
11.
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid ß In Vivo.
ACS Med Chem Lett
; 13(1): 76-83, 2022 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35059126
12.
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 20(1): 294-8, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19906529
13.
Characterization of the interaction between platelet factor 4 and homogeneous synthetic low molecular weight heparins.
J Thromb Haemost
; 18(2): 390-398, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31573759
14.
Evaluation of a Series of ß-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.
ACS Med Chem Lett
; 10(8): 1159-1165, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413800
15.
Optimization of 1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.
J Med Chem
; 61(12): 5292-5303, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29809004
16.
Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma.
PLoS One
; 11(3): e0150479, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26967324
17.
Partially desulfated heparin modulates the interaction between anti-protamine/heparin antibodies and platelets.
Thromb Haemost
; 115(2): 324-32, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26423467
18.
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
Eur J Med Chem
; 40(6): 597-606, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15922843
19.
Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria.
Thromb Haemost
; 114(6): 1189-98, 2015 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26225544
20.
1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.
J Med Chem
; 58(20): 8216-35, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378740