Semantic interference and its control: A functional neuroimaging and connectivity study.

During picture naming, the ease with which humans generate words is dependent upon the context in which they are named. For instances, naming previously presented items results in facilitation. Instead, naming a picture semantically related to previous items displays persistent interference effects (i.e., cumulative semantic interference, CSI). The neural correlates of CSI are still unclear and it is a matter of debate whether semantic control, or cognitive control more in general, is necessary for the resolution of CSI. We carried out an event-related fMRI experiment to assess the neural underpinnings of the CSI effect and the involvement and nature of semantic control. Both left inferior frontal gyrus (LIFG) and the left caudate nucleus (LCN) showed a linear increase of BOLD response positively associated with the consecutive number of presentations of semantically related pictures independently of task-load. The generalized psychophysiological interaction analysis showed that LIFG demonstrated a quantitative neural connectivity difference with the left supramarginal and angular gyri for increases of task-load and with the fusiform gyri for linear CSI increases. Furthermore, seed-to-voxel functional connectivity showed that LIFG activity coupled with different regions involved in cognitive control and lexicosemantic processing when semantic interference was elicited to a minimum or maximum degree. Our results are consistent with the lexical-competitive nature of the CSI effect, and we provide novel evidence that semantic control lies upon a more general cognitive control network (i.e., LIFG and LCN) responsible for resolving interference between competing semantically related items through connectivity with different brain areas in order to guarantee the correct response. Hum Brain Mapp 37:4179-4196, 2016. © 2016 Wiley Periodicals, Inc.

On predicting others' words: electrophysiological evidence of prediction in speech production.

The present study investigated whether lexical processes that occur when we name objects can also be observed when an interaction partner is naming objects. We compared the behavioral and electrophysiological responses of participants performing a conditional go/no-go picture naming task in two different conditions: individually and jointly with a confederate participant. To obtain an index of lexical processing, we manipulated lexical frequency, so that half of the pictures had corresponding names of high-frequency and the remaining half had names of low-frequency. Color cues determined whether participants should respond, whether their task-partner should respond, or whether nobody should respond. Behavioral and ERP results showed that participants engaged in lexical processing when it was their turn to respond. Crucially, ERP results on no-go trials revealed that participants also engaged in lexical processing when it was their partner's turn to act. In addition, ERP results showed increased response inhibition selectively when it was the partner's turn to act. These findings provide evidence for the claim that listeners generate predictions about speakers' utterances by relying on their own action production system.